Essential Cell Biology
Essential Cell Biology
4th Edition
ISBN: 9780815344544
Author: Keith Roberts, Karen Hopkin, Alexander D Johnson, Martin Raff, Dennis Bray, Bruce Alberts, Julian Lewis, Peter Walter
Publisher: TAYLOR
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Chapter 15, Problem 15Q
Summary Introduction

To explain: The fate of a protein which contains an ER signal sequence at its N-terminus and a nuclear localization sequence in its middle.

Concept introduction: Signal sequences are the small stretches of polypeptides present at the N-terminal position of many newly-produced proteins located inside certain organelles, or incorporated with many cellular membranes with a definite destination. Synthesis and target achieving would be possible only if the signal sequences were present in the N-terminal part of the protein. The amino acids that make up the signal sequences too have significant importance in directing the protein to its destiny.

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