ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
expand_more
expand_more
format_list_bulleted
Videos
Textbook Question
Chapter 15, Problem 23P
In 1988, neurologists in Australia reported the existence of identical twins who had developed myoclonic epilepsy in their teens. One twin remained only mildly affected by this condition, but the other twin later developed other symptoms of full-blown MERRF, including deafness, ragged red fibers, and ataxia (loss of the ability to control muscles). Explain the
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Shown below is a pedigree for Phenylketonuria (PKU), an autosomal recessive metabolic disorder. The characteristic feature of PKU is severe mental retardation
A) What is the probability that individual II-1 is heterozygous for this gene?
B) What is the probability that individual III-4 is heterozygous for this gene?
C) If individuals III-3 and III-4 were to marry, what is the probability that their child would express PKU?
Consider a Droscophilia fly with a genotype of Nn XqYY. The dominant allele of the sex-linked gene specifies a black body and the recessive a white body. The recessive autosomal allele specifies hairy bristles while the dominant allele specifies smooth bristles.
i)What is the ploidy of this fly?
ii) What would the sex of this fly be?
iii)What would the phenotype of this fly be with respect to these two loci?
6). To investigate the genetic control of locomotive
behavior in the diploid nematode, Caenorhabditis
elegans, eight "wiggly" mutants were isolated,
which wiggle in an uncoordinated way rather than
smoothly gliding. These eight mutants were crossed
together in all possible pairwise combinations,
yielding the results summarized in the table above (+
means that all the progeny were wild type, and m
means that all the progeny showed the wiggly
mutant phenotype). Organize the eight mutations
into con lementation groups, each consisting of a group of mutations affecting the same gene.
1
2
3
4
5
6
7
8
1
E
N+E
2
3+1
m +
m
4 5
+ m m
E+
+ +
EE
6
++E
E+
+EE
m m
+ +
+ + +
+ +
+ +
m
7 8
++4
∞+E
+E
m
m
++ E
Chapter 15 Solutions
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
Ch. 15 - Match each numbered item with the most closely...Ch. 15 - Assuming human cells have on average 1000...Ch. 15 - Reverse translation is a term given to the process...Ch. 15 - The human nuclear genome encodes tRNAs with 32...Ch. 15 - The human mitochondrial genome includes no genes...Ch. 15 - How do you know if the halibut you purchased at...Ch. 15 - Is each of these statements true of chloroplast or...Ch. 15 - Suppose you are characterizing the DNA of a...Ch. 15 - An example of a gene-targeting DNA plasmid vector...Ch. 15 - Which of the following characteristics of...
Ch. 15 - The Saccharomyces cerevisiae nuclear gene ARG8...Ch. 15 - The so-called hypervariable regions HV1 and HV2 of...Ch. 15 - Suppose a new mutation arises in a mitochondrial...Ch. 15 - Describe at least two ways in which the...Ch. 15 - Why are severe mitochondrial or chloroplast gene...Ch. 15 - Suppose you are examining a newly found plant...Ch. 15 - A form of male sterility in corn is inherited...Ch. 15 - Plant breeders have long appreciated the...Ch. 15 - A mutant haploid strain of Saccharomyces...Ch. 15 - Prob. 20PCh. 15 - What characteristics in a human pedigree suggest a...Ch. 15 - The first person in the family represented by the...Ch. 15 - In 1988, neurologists in Australia reported the...Ch. 15 - If you were a genetic counselor and had a patient...Ch. 15 - Kearns-Sayre syndrome KSS, Pearson syndrome, and...Ch. 15 - Many clinically relevant mitochondrial diseases...Ch. 15 - Leigh syndrome is characterized by psychomotor...Ch. 15 - All mutations in mitochondrial genes ultimately...Ch. 15 - How could researchers have determined that the...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- To understand the genetic basis of locomotion in the diploid nematode Caenorhabditis elegans, recessive mutations were obtained, all making the worm “wiggle” ineffectually instead of moving with its usual smooth gliding motion. These mutations presumably affect the nervous or muscle systems. Twelve homozygous mutants were intercrossed, and the F1 hybrids were examined to see if they wiggled. The results were as follows, where a plus sign means that the F1 hybrid was wild type (gliding) and “w” means that the hybrid wiggled.a. Explain what this experiment was designed to test. b. Use this reasoning to assign genotypes to all 12 mutants. c. Explain why the phenotype of the F1 hybrids between mutants 1 and 2 differed from that of the hybrids between mutants 1 and 5arrow_forwardIn 1995, doctors reported a Chinese family in whichretinitis pigmentosa (progressive degeneration of theretina leading to blindness) affected only males. Allsix sons of affected males were affected, but all of thefive daughters of affected males (and all of thechildren of these daughters) were unaffected.a. What is the likelihood that this form of retinitispigmentosa is due to an autosomal mutationshowing complete dominance?b. What other possibilities could explain the inheritance of retinitis pigmentosa in this family? Whichof these possibilities do you think is most likely?arrow_forwardConsider the following three autosomal recessive mutations in Drosophila:vestigial wings (v); wild type is long (v+)black body color (b); wildtype is gray (b+)plum eyes (p); wildtype is red (p+)A vestigal, gray, red female (homozygous for all three genes) is crossed with a long wing, black, plum male (homozygous for all three genes). The F1 female progeny are mated with triple homozygous recessive males. Here is the phenotypic data for the F2 progeny:vestigal; gray; red 580long wings; black; plum 592vestigal; black; red 45long; gray; plum 40vestigal; black; plum 89long; gray; red 94vestigal; gray; plum 3long; black; red 5A total of 1448 progeny were counted.Which one of the following values is the approximate distance between the plum eye color and black body color loci?arrow_forward
- Two different female Drosophila were isolated, each heterozygous for the autosomally linked genes black body (b), dachs tarsus (d), and curved wings (c). These genes are in the order d–b–c, with b closer to d than to c. Shown in the following table is the genotypic arrangement for each female, along with the various gametes formed by both. Identify which categories are noncrossovers (NCO), single crossovers (SCO), and double crossovers (DCO) in each case. Then, indicate the relative frequency with which each will be produced.arrow_forwardWhat is a genetic reason for the absence of Labrador-shaped dogs that are a wolf-like gray (agouti) in color?arrow_forwardBlack body (b) and purple eye (pr) are recessive autosomal mutations in Drosophila. Bridges are crossed b/b females with pr/pr males and in the F2 observed 684 wild type, 371 black-bodied, and 300 purple-eyed flies. Do these results indicate that the b and pr genes are closely linked? Explain. (Remember that there is no crossing-over in male Drosophila)..arrow_forward
- Kinky hairs and long nose whiskers in rats are produced in response to therecessive gene (k), and a short stubby tail is produced by the recessive gene (st).The 2 loci of are 30 CM apart. What is the F phenotypic proportions from across between a heterozygous trans female rat, and a heterozygous cis male rat?arrow_forwardConcordance studies of twins for a neurodegenerative disorder show MZ= 46% and DZ= 15%. Further studies have shown a possible link to a gene on chromosome 9, however, there are some individuals in the study who have the allele but do not develop the disorder (group 1), and there are other individuals who do not have the allele yet develop the disorder (group 2). Amita's older sister and maternal uncle have this disorder. Currently, Amita & her 2 younger brothers do not show symptoms. Amita's paternal grandfather was rumored to have this disorder. 1. Draw the pedigree for Amita's family and determine the mode of inheritance if any. 2. Explain how the 2 groups in the study could be possible? 3. What would you tell Amita about the heritability of this disorder?arrow_forwardConsider two hypothetical recessive autosomal genes a and b, where a heterozygote is testcrossed to a double- homozygous mutant. Predict the phenotypic ratios under the following conditions: (a) a and b are located on separate autosomes. (b) a and b are linked on the same autosome but are so far apart that a crossover always occurs between them. (c) a and b are linked on the same autosome but are so close together that a crossover almost never occurs.arrow_forward
- In the nematode C. elegans, homozygosity for the e mutant allele causes an extreme "uncoordinated" phenotype, where the worm completely loses its ability to move. Examination of 100 individuals with genotype e/e reveals that 60 mutant worm can't move at all, 35 show a very reduced ability to move, and the remaining 5 seem to have a completely wild-type phenotype with respect to movement ability. These observations suggest that e has O incomplete penetrance and variable expressivity O low expressivity and variable penetrance Ohigh expressivity and variable penetrance O high penetrance and incomplete expressivityarrow_forward1. Please consider the following pedigree. I 1 II 1 a) Assume that colour is controlled by a single sex-influenced gene where green is expressed preferentially in males. Individuals I-1 and I-2 are homozygous for red and green respectively. Which individual/s in generation II will be red? b) If colour is a controlled by cytoplasmic DNA, which individual/s in generation II will be green?arrow_forwardMale Drosophila from a true-breeding wild-type stock were irradiated with X-rays and then mated with females from a true-breeding stock carrying the following recessive mutations on the X chromosome: yellow body (y), crossveinless wings (cv), cut wings (ct), singed bristles (sn), and miniature wings (m). These markers are known to map in the order: Recessive alleles: y, cv, ct, sn, m Dominant alleles: y+, cv+, ct+, sn+, m+ y-cv-ct-sn-m у CV ct sn m X-rays х х X ct sn CV у m y+ CV+ ct+ sn+ m+ х X ? Exceptional female: Most of the female progeny of this cross were phenotypically wild type, but one female exhibited ct and sn mutant characteristics. When this exceptional ct sn female was mated with a male from the true-breeding wild-type stock, twice as many females as males appeared among the progeny. a. What is the nature of the X-ray-induced mutation present in the exceptional female? b. Draw the X chromosomes present in the exceptional ct sn female as they would appear during pairing…arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Embryology | Fertilization, Cleavage, Blastulation; Author: Ninja Nerd;https://www.youtube.com/watch?v=8-KF0rnhKTU;License: Standard YouTube License, CC-BY