Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 15, Problem 2Q
Summary Introduction
To review:
The description of mutation, which would affect nucleotides, outside the coding region of a gene (beta-globin gene).
Introduction:
Mutations are permanent and heritable changes of the genome. They can result in diseases by altering the protein sequences. An altered protein sequence either folds incorrectly or does not fold at all. This consequence can render a protein dysfunctional and can cause diseases in the organism.
Expert Solution & Answer
Trending nowThis is a popular solution!
Students have asked these similar questions
Name three different types of loss of function mutations and in each case explain how the mutation exerts a loss of function effect on a gene
In the fX174 genome, describe the difference between how thegene B and gene A* proteins are made
Explain how mutations occuro How do SNPs arise?describe one example of an SNP cause of a geneticdisease describe one example of an SNP that resulted in anadvantage to the organism.
Chapter 15 Solutions
Life: The Science of Biology
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Explain the Mutations at the Huntington disease locus are caused by an expansion of a trinucleotide repeat SSR in a coding region.arrow_forwardWhat mutations are possible in gene ZFPM2?arrow_forwardThe genetic alteration responsible for sickle-cell anemia in humans involves: a transition mutation from A to G, substituting glutamic acid for valine in a-globin a transversion mutation from T to A, substituting valine for glutamic acid in b-globin a transition mutation from T to C, substituting valine for glutamic acid in b-globin a transversion mutation from G to C, substituting glutamic acid for valine in a-globin a frameshift mutation of one ATC codon, removing glutamic acid from b-globinarrow_forward
- Which of the above mutations will result in a shift in the reading frame?arrow_forwardExplain the effect of one, two or all three introns removal from the Hes7 gene would reduce the delay the production of the unstable Hes7 gene.arrow_forwardThere are five substitution mutations in the dark-colored mutant Mc1r gene. Compare the DNA sequence of the light-colored wild-type Mc1r gene with the DNA sequence of the dark-colored mutant Mc1r gene. Indicate the locations of the five mutations by changing the font color to YELLOW for the five single DNA nucleotides that are mutated in the mutant Mc1r gene table. Using the information in the introduction, determine whether each of these mutations is a silent, missense, or nonsense mutation. Using the mutant Mc1r gene data, fill in the columns (including DNA, mRNA, and amino acid) in gene table 2 that contain a silent mutation with BLUE. Likewise, fill in the columns that contain a missense mutation with RED. Shade any columns that contain nonsense mutations with GREEN. Then Of the five mutations you identified in the mutant Mc1r gene, how many are: substitutions insertions deletions (Enter a number on each line.) 2. Of the five mutations…arrow_forward
- The protein encoded by the cystic fibrosis gene is 1480amino acids long, yet the gene spans 250 kb. How is thisdifference possible?arrow_forwardWhy can it be said that transcription of thebacteriophage T7 genome requires two enzymes?arrow_forwardBased on the information in Figure, which single-nucleotide mutationevent is more likely: Arg-to-His, or Arg-to-Ser? Explain.arrow_forward
- A molecular geneticist hopes to find a Gene in human liver cell that codes for an important blood-clotting protein,he knows that the nucleotide sequence of a small part of the Gene is GTGGACTGACA.briefly explain how to obtain genearrow_forwardIn Figure 12-4, certain mutations decrease the relativetranscription rate of the β-globin gene. Where are thesemutations located, and how do they exert their effects ontranscription?arrow_forwardThe HbβS(sickle-cell) allele of the human β-globingene changes the sixth amino acid in the β-globinchain from glutamic acid to valine. In HbβC, the sixthamino acid in β-globin is changed from glutamic acidto lysine. What would be the order of these two mutations within the map of the β-globin gene?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
What Is A Virus ? ; Author: Peekaboo Kidz;https://www.youtube.com/watch?v=YS7vsBgWszI;License: Standard YouTube License, CC-BY