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Pediatric literature has reported many cases of poisoning in children with Lomotil, an antidiarrheal medicine. Lomotil works primarily by means of the morphinelike effects of its chief ingredient, diphenoxylate, but it also contains atropine. Considering the mode of action described for atropine in Deqier Insight 15 2, why might it contribute to the antidiarrheal effect of Lomotil? In atropine poisoning, would you expect the pupils to be dilated or constricted? The skin to be moist or dry? The heart rate to be elevated or depressed? The bladder to retain urine or void uncontrollably? Explain each answer. Atropine poisoning is treated with physostigmine, a cholinesterase inhibitor. Explain the rationale of tins treatment.
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