Chapter 15, Problem 7P

(a)

Summary Introduction

To calculate: The ratio of [P_i] to [glucose-1-phosphate] when the reaction is at equilibrium.

Introduction:

The enzyme glycogen phosphorylase is used in the glucose removal from glycogen. The physiological function of glycogen phosphorylase in skeletal muscle and liver is to catalyze the conversion of glycogen into glucose 1-phosphate and glucose 6-phosphate into glucose respectively.

(b)

Summary Introduction

To determine: The direction of metabolite flow through the glycogen phosphorylase reaction in muscle when the measure ratio $\frac{\left[{\text{P}}_{\text{i}}\right]}{\left[\text{glucose}\text{1-phosphate}\right]}$ in myocytes is more than 100:1 under physiological conditions.

Introduction:

The enzyme glycogen phosphorylase is used in the glucose removal from glycogen. The physiological function of glycogen phosphorylase in skeletal muscle and liver is to catalyze the conversion of glycogen into glucose 1-phosphate and glucose 6-phosphate into glucose respectively.

(c1)

Summary Introduction

To determine: The reason for different equilibrium and physiological ratios.

Introduction:

The enzyme glycogen phosphorylase is used in the glucose removal from glycogen. The physiological function of glycogen phosphorylase in skeletal muscle and liver is to catalyze the conversion of glycogen into glucose 1-phosphate and glucose 6-phosphate into glucose respectively.

(c2)

Summary Introduction

To determine: The possible significance of the difference in equilibrium and physiological ratios.

Introduction:

The enzyme glycogen phosphorylase is used in the glucose removal from glycogen. The physiological function of glycogen phosphorylase in skeletal muscle and liver is to catalyze the conversion of glycogen into glucose 1-phosphate and glucose 6-phosphate into glucose respectively.