Biology
5th Edition
ISBN: 9781260487947
Author: BROOKER
Publisher: MCG
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Chapter 15.2, Problem 3EQ
Summary Introduction
To describe: The way in which the result of the Lederberg supports or falsifies the hypothesis.
Introduction: The randomness in the mutation rate was shown by Lederberg in “replica plate experiment.” The minute changes in the “DNA fragment” caused the very new variations among the individuals which makes them different from each other. In mutations, sudden variations take place in the body of an organism which can be either beneficial or can cause damage to the body of an organism.
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Chapter 15 Solutions
Biology
Ch. 15.1 - Consequences of Mutations Concept Check: Based on...Ch. 15.1 - Prob. 2CCCh. 15.2 - Prob. 1EQCh. 15.2 - Prob. 2EQCh. 15.2 - Prob. 3EQCh. 15.2 - Prob. 1CCCh. 15.3 - DNA Repair Concept Check: Which components of the...Ch. 15.3 - Why is this person so sensitive to sunlight?...Ch. 15.4 - Prob. 1CCCh. 15.4 - Prob. 2CS
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- what does thi statement means Disease-Causing MutationsAre Hidden in a Sea of Variation?arrow_forwardLuria and Delbruck's experiemnt demonstatred that mutation of genetic materials is a random event in bacteria mutation of genetic materials is due to mutagens mutation of genetic materials is directed changed in bacteria dna is a genetic material in e coli cellsarrow_forward1. ls a random mutation more likely to be beneficial or harmful? Explain your answer 2. Distinguish between spontaneous and induced mutations. Which are more harmful? Which are avoidable?arrow_forward
- To determine the reproducibility of mutation fre-quency measurements, you do the following experiment.You inoculate each of 10 cultures with a single E. coli bac-terium, allow the cultures to grow until each contains 106cells, and then measure the number of cells in each culturethat carry a mutation in your gene of interest. You were sosurprised by the initial results that you repeated the experi-ment to confirm them. Both sets of results display the sameextreme variability, as shown in Table Q5–1. Assuming thatthe rate of mutation is constant, why do you suppose thereis so much variation in the frequencies of mutant cells indifferent cultures?arrow_forwardPrice et al. [(1999). J. Bacteriol. 181:2358–2362] conducteda genetic study of the toxin transport protein (PA) of Bacillusanthracis, the bacterium that causes anthrax in humans. Withinthe 2294-nucleotide gene in 26 strains they identified five pointmutations—two missense and three synonyms—among differentisolates. Necropsy samples from an anthrax outbreak in 1979revealed a novel missense mutation and five unique nucleotidechanges among ten victims. The authors concluded that thesedata indicate little or no horizontal transfer between differentB. anthracis strains. Question: Which types of nucleotide changes (missense or synonyms)cause amino acid changes?arrow_forwardPrice et al. [(1999). J. Bacteriol. 181:2358–2362] conducteda genetic study of the toxin transport protein (PA) of Bacillusanthracis, the bacterium that causes anthrax in humans. Withinthe 2294-nucleotide gene in 26 strains they identified five pointmutations—two missense and three synonyms—among differentisolates. Necropsy samples from an anthrax outbreak in 1979revealed a novel missense mutation and five unique nucleotidechanges among ten victims. The authors concluded that thesedata indicate little or no horizontal transfer between differentB. anthracis strains. Question: On what basis did the authors conclude that evidence ofhorizontal transfer is absent from their data?arrow_forward
- Price et al. [(1999). J. Bacteriol. 181:2358–2362] conducteda genetic study of the toxin transport protein (PA) of Bacillusanthracis, the bacterium that causes anthrax in humans. Withinthe 2294-nucleotide gene in 26 strains they identified five pointmutations—two missense and three synonyms—among differentisolates. Necropsy samples from an anthrax outbreak in 1979revealed a novel missense mutation and five unique nucleotidechanges among ten victims. The authors concluded that thesedata indicate little or no horizontal transfer between differentB. anthracis strains. Question: What is meant by ”horizontal transfer”?arrow_forwardExplain how the fluctuation test and replica plating haveshown that mutations arise randomly andspontaneouslyarrow_forwardBriefly explain the frameshift mutation ?arrow_forward
- https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TP73 using the above linke, Briefly describe the most common mutation found in this gene. Include details about the type of mutation, and the predicted effect. . where does the mutation occur, what bases are changed; does the mutation change the protein sequence, and if so what would the likely biologics consequences be?arrow_forwardDiscuss the sequencing technology used to resolve the human genome in 2005, its significant advantages and limitations?arrow_forwardWhy do frameshift mutations generally have more seriousconsequences than missense mutations?arrow_forward
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY