Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 17, Problem 12PDQ
Many promoter regions contain CAAT boxes containing consensus sequences CAAT or CCAAT approximately 70 to 80 bases upstream from the transcription start site. How might one determine the influence of CAAT boxes on the transcription rate of a given gene?
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Many promoter regions contain CAAT boxes containing consensus sequences CAAT or CCAAT approximately 70 to 80 bases upstream from the transcription start site. How might one determine the influence of CAAT boxes on the transcription rate of a given gene?
The following logo plot represents the preferred cis-regulatory sequences (i.e.
transcription factor binding site) of bHLH transcription factor FOSL1.
C
1 2 3 4 5 6 7 8 9 10 11
position
Would you expect this sequence to be recognized by a monomer, a homodimer, or a
heterodimer of the protein? Explain your answer.
(short phrases are sufficient; please write your answer into the template below)
A-
В I
A -l expect FOSL1 to bind as a:
(monomer, homodimer, heterodimer; please choose)
B - short explanation:
information content (bit)
!!
"Upstream"
"Downstream"
Exons
Start of
transcription
Termination codon
5
3'
Promoter
initiator
codon
Introns
Polyadenylation
signal
(intervening sequences)
5' untranslated
region
3' untranslated
region
Direction of transcription
Please study the diagram above on eukaryotic gene expression. In order to
provide instructions for gene expression, a eukaryotic gene should have the
following sequences except for
O A. Promoter
B. Start codon also known as initiator codon
C. Splicing signals (dinucleotide sequence in the intron)
O D. 5' CAP sequence
Chapter 17 Solutions
Concepts of Genetics (11th Edition)
Ch. 17 - Cancer cells often have abnormal patterns of...Ch. 17 - The hormone estrogen converts the estrogen...Ch. 17 - Prob. 3NSTCh. 17 - Prob. 1CSCh. 17 - A man in his early 30s suddenly developed weakness...Ch. 17 - Prob. 3CSCh. 17 - Prob. 1PDQCh. 17 - Prob. 2PDQCh. 17 - Prob. 3PDQCh. 17 - Provide a definition of chromatin remodeling, and...
Ch. 17 - Describe the organization of the interphase...Ch. 17 - A number of experiments have demonstrated that...Ch. 17 - Prob. 7PDQCh. 17 - Present an overview of the manner in which...Ch. 17 - Distinguish between the cis-acting regulatory...Ch. 17 - Describe the manner in which activators and...Ch. 17 - Compare the control of gene regulation in...Ch. 17 - Many promoter regions contain CAAT boxes...Ch. 17 - Prob. 13PDQCh. 17 - Present an overview of RNA-induced gene silencing...Ch. 17 - Prob. 15PDQCh. 17 - Prob. 16PDQCh. 17 - DNA supercoiling, which occurs when coiling...Ch. 17 - Prob. 18PDQCh. 17 - Prob. 19PDQCh. 17 - Prob. 20ESPCh. 17 - Prob. 21ESPCh. 17 - Because the degree of DNA methylation appears to...Ch. 17 - Prob. 23ESPCh. 17 - Prob. 24ESPCh. 17 - Prob. 25ESPCh. 17 - Prob. 26ESPCh. 17 - Prob. 27ESPCh. 17 - Prob. 28ESPCh. 17 - During an examination of the genomic sequences...Ch. 17 - Transcription factors play key roles in the...
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- Consider the Rho-dependent terminator sequence 5’CCCAGCCCGCCUAAUGAGCGGCCUUUUUUUU-3’. What affect would a point mutation at any one of the bolded and underlined nucleotides disrupt termination of transcription? Group of answer choices Mutation in one of these nucleotides would disrupt base pairing, preventing the formation of the hairpin and disrupting termination. Mutation in one of these nucleotides would have no affect on base pairing, so the termination hairpin is formed and termination proceeds. Mutation in one of these nucleotides would not disrupt base pairing, but would prevent the formation of the hairpin and disrupt termination. Mutation in one of these nucleotides would disrupt base pairing, but not affect the formation of the hairpin and termination proceeds.arrow_forwardMany eukaryotic promoter regions contain CAAT boxes with consensus sequences CAAT or CCAAT approximately 70 to 80 bases upstream from the transcription start site. How might one determine the influence of CAAT boxes on the transcription rate of a given gene?arrow_forwardSeveral examples of antisense RNA regulating translation in bacterial cells have been discovered. Molecular geneticists have also used antisense RNA to artificially control transcription in both bacterial and eukaryotic genes. If you wanted to inhibit the transcription of a bacterial gene with antisense RNA, what sequences might the antisense RNA contain?arrow_forward
- The following DNA nucleotides are found near the end of a bacterial transcription unit. 3′–AGCATACAGCAGACCGTTGGTCTGAAAAAAGCATACA–5′ Q. Is this terminator rho independent or rho dependent?arrow_forwardIdentify the statements that are features of a promoter. In prokaryotes, the promoter contains a −35 and −10 region upstream of the transcription start site. In prokaryotes, the promoter is recognized by general transcription factors (GTF), which recruit the RNA polymerase holoenzyme. In both prokaryotes and eukaryotes, the promoter is located in the 5' direction, upstream from the transcription start site. In eukaryotes, the promoter recruits the preinitiation complex, which includes the TATA-binding protein. In eukaryotes, the promoter attracts the small and large ribosomal subunits with the help of initiation factors.arrow_forwardConsider the Rho-dependent terminator sequence 5’CCCAGCCCGCCUAAUGAGCGGCCUUUUUUUU-3’. What affect would a point mutation at any one of the bolded and underlined nucleotides disrupt termination of transcription? Group of answer choices 1.Mutation in one of these nucleotides would disrupt base pairing, but not affect the formation of the hairpin and termination proceeds. 2.Mutation in one of these nucleotides would have no affect on base pairing, so the termination hairpin is formed and termination proceeds. 3.Mutation in one of these nucleotides would not disrupt base pairing, but would prevent the formation of the hairpin and disrupt termination. 4.Mutation in one of these nucleotides would disrupt base pairing, preventing the formation of the hairpin and disrupting termination.arrow_forward
- 4.1 Name and discuss two transcription regulatory elements that can be found in the figure. (6)4.2. During the activation of eukaryotic transcription the promoter region needs to be accessible for the binding of transcription factors. Describe in detail one of the mechanisms involved in this process.arrow_forwardThe consensus sequence for the –35 sequence of a bacterial promoter is 5′–TTGACA–3′. The –35 sequence of a particular bacterial gene is 5′– TTAACA–3′. A mutation changes the fifth base from a C to a G. Would you expect this mutation to increase or decrease the rate of transcription?arrow_forwardThe interphase nucleus is a highly structured organelle with chromosome territories, interchromatin compartments, and transcription factories. In cultured human cells, researchers have identified approximately 8000 transcription factories per cell, each containing an average of eight tightly associated RNAP II molecules actively transcribing RNA. If each RNAP II molecule is transcribing a different gene, how might such a transcription factory appear? Provide a simple diagram that shows eight different genes being transcribed in a transcription factory and include the promoters, structural genes, and nascent transcripts in your presentation.arrow_forward
- A bacterial species has a hypothetical sigma promoter that has the following sequence: TTGGCA - 18 bases - TATAAT What change in the level of transcription would there be if the sequence was mutated to: TTCGCA -18 bases -TATAAT O The mutation would bind the promoter to the consensus and produce normal levels of transcription O The mutation would inhibit the promoter thereby inhibiting transcription The mutation would move the promoter away from consensus and reduce the level of transcription O No change the consensus TATAAT sequence in the same. D00 F3 F4 F5 F6 F7 F8 F9 % & 5 6 7 8 9 %24arrow_forwardFor each of the following initiation factors, how would eukaryotic initiation of translation be affected if it were missing? A. eIF 2 B. eIF4 C. eIF5arrow_forwardIntrons in protein-coding genes of some eukaryotes are rarely shorter than 65 nucleotides long. What might be a rationale for this limitation?arrow_forward
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