Interpretation:
The details of the mechanism for the reaction between mixed anhydride and Z-Ala-Leu, and how carbon dioxide and ethanol are formed in the mechanisms are to be discussed.
Concept introduction:
The reaction between nucleophile and acyl compounds is called nucleophilic acyl substitution.
Nucleophilic acyl substitution describe a class of substitution reactions involving nucleophiles and acyl compounds. In this type of reaction, a nucleophile—such as an alcohol, amine, or enolate—displaces the leaving group of an acyl derivative—such as an acid halide, anhydride, or ester.
A mixed anhydride is a
Acid chlorides react with
The carboxylic acid is converted into acid chlorides in the presence of thionyl chloride.
Decarboxylation is the loss of carbon dioxide.
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ORGANIC CHEM. VOL.1+2-W/WILEYPLUS
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