Essential Organic Chemistry (3rd Edition)
3rd Edition
ISBN: 9780321937711
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Chapter 17, Problem 41P
(a)
Interpretation Introduction
Interpretation:
The location and type of charge of given hexapeptide at
(b)
Interpretation Introduction
Interpretation:
The location and type of charge of given hexapeptide at
(c)
Interpretation Introduction
Interpretation:
The location and type of charge of given hexapeptide at pH 7.0 has to be drawn.
(d)
Interpretation Introduction
Interpretation:
The location and type of charge of given hexapeptide at
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Chapter 17 Solutions
Essential Organic Chemistry (3rd Edition)
Ch. 17.1 - a. Explain why, when the imidazole ring of...Ch. 17.2 - Prob. 2PCh. 17.3 - Prob. 3PCh. 17.3 - Prob. 4PCh. 17.3 - Prob. 6PCh. 17.4 - Calculate the pI of each of the following amino...Ch. 17.4 - a. Which amino acid has the lowest pI value? b....Ch. 17.5 - What aldehyde is formed when valine is treated...Ch. 17.5 - Prob. 10PCh. 17.5 - Prob. 11P
Ch. 17.5 - Prob. 12PCh. 17.6 - Prob. 13PCh. 17.6 - What amino acid would be formed using the...Ch. 17.6 - What amino acid would be formed when the aldehyde...Ch. 17.7 - Pig liver esterase is an enzyme that catalyzes the...Ch. 17.8 - Prob. 17PCh. 17.8 - Prob. 18PCh. 17.8 - Prob. 19PCh. 17.8 - Prob. 20PCh. 17.10 - Prob. 21PCh. 17.10 - Prob. 22PCh. 17.10 - Why does cyanogen bromide not cleave on the C-side...Ch. 17.10 - Prob. 24PCh. 17.10 - Prob. 26PCh. 17.12 - Prob. 27PCh. 17.13 - a. Which would have the greatest percentage of...Ch. 17 - Draw the predominant form of the following amino...Ch. 17 - What is the pI of serine?Ch. 17 - Prob. 31PCh. 17 - Prob. 32PCh. 17 - Which would have a higher percentage of negative...Ch. 17 - Draw the form of aspartate that predominates at...Ch. 17 - Prob. 35PCh. 17 - A professor was preparing a manuscript for...Ch. 17 - a. Why is the pKa of the glutamate side chain...Ch. 17 - Prob. 38PCh. 17 - Determine the amino acid sequence of a polypeptide...Ch. 17 - Prob. 40PCh. 17 - Prob. 41PCh. 17 - Three peptides were obtained from a trypsin...Ch. 17 - Prob. 43PCh. 17 - After the polypeptide shown here was treated with...Ch. 17 - The disulfide bridges of a polypeptide were...Ch. 17 - -Amino acids can be prepared by treating an...Ch. 17 - Reaction of a polypeptide with carboxypeptidase A...Ch. 17 - Prob. 48PCh. 17 - Prob. 49PCh. 17 - Show how valine can be prepared by a. a Strecker...Ch. 17 - Prob. 51PCh. 17 - Why is proline never found in an -helix?Ch. 17 - Determine the amino acid sequence of a polypeptide...Ch. 17 - Prob. 55PCh. 17 - A chemist wanted to test his hypothesis that the...Ch. 17 - A normal polypeptide and a mutant of the...
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- Consider the tripeptide Thr-Arg-Tyr. 1. Name: T-R-Y_______________________ 2. Draw the structure of the fully protonated form of the tripeptide and label the ionizable groups with the corresponding pKa values. 3. Draw predominant structure of the tripeptide at pH 11. What is the net charge? Consider the image as an example. Thank you.arrow_forwardWhat is the net charge on the tripeptide His-Glu-Lys at pH 7? The table below gives the pKa's of the ionizable groups on the free amino acids Free AA pKa of COO- pKa of NH3+ His 1.8 9.2 Glutamate 2.2 9.7 Lysine 2.2 9.1 a. -2 b. -1 c. 0 d. +1 e. +2arrow_forwardConsider the pentapeptide Ile-Lys-Asp-Phe-Gly and answer the following (use the pKa values in the table): 1. Draw the structure of the predominant form of the pentapeptide at pH = 12. 2. Draw the structure of the Zwitterion form of the pentapeptide. 3. What is the IpH of the peptide? Handwritten solutionarrow_forward
- Draw the most stable chemical structure for the following peptide, at pH=12: Cys-Phe-Lys-Val-Tyr pKa Values: Tyr pK1=2.20; pK2=9.11 Cys pK1=1.96; pK2=10.28arrow_forwardConsider the pentapeptide Ile-Lys-Asp-Phe-Gly and answer the following (use the pKa values in the table): 1. Draw the structure of the predominant form of the pentapeptide at pH = 12. 2. Draw the structure of the Zwitterion form of the pentapeptide. 3. What is the IpH of the peptide?arrow_forwardEstimate the pI of each tripeptide in Problem 27.46. Draw a structural formula of these tripeptides. Mark each peptide bond, the N-terminal amino acid, and the C-terminal amino acid. (a) Phe-Val-Asn (b) Leu-Val-Glnarrow_forward
- The octapeptide angiotensin II has the sequence Asp-Arg-Val-Tyr-Ile-His-Pro- Phe. What fragments would result if angiotensin II were cleaved with trypsin? With chymotrypsin?arrow_forwardThe pKa for the side chain amino group in lysine is 10.4. If we were working at physiological pH 7.4, what would be the ratio of the protonated to unprotonated versions of lysine? a. 1000:1 b. 3:1 c. 1:1000 d. 1:3arrow_forwardExplain why the pKa of the ‒ NH3+ group of an α-amino acid is lower than the pKa of the ammonium ion derived from a 1° amine (RNH3+). For example the pKa of the ‒ NH3+ group of alanine is 9.87 but the pKa of CH3NH3+ is 10.63.arrow_forward
- What is the net charge (approximately) on the polypeptide shown below at pH 12.5? Lys – Arg – Val – Cys – Gluarrow_forwardDraw the peptide CHEMISTRY. a. What is the full name and 3-letter abbreviation of this peptide? b. Give the different forms (charges) of the peptide as it is titrated from pH 1.5 until pH 12.0. c. What is the isoelectric point of the peptide?arrow_forwardGiven the chart of pKa’s below, calculate the isoelectric point for tyrosinearrow_forward
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