GENETIC ANALYSIS: INTEGRATED - ACCESS
3rd Edition
ISBN: 9780135349298
Author: Sanders
Publisher: PEARSON
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Chapter 17, Problem 5P
Draw a graph depicting the relative amounts of nuclear DNA present in the different stages of the cell cycle (
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Draw a diagram of the cell cycle and label the phases. On your diagram:
a) For each phase, indicate whether the chromosomes are condensed or not.
b) Indicate the phase(s) when it is possible to do a karyotype
c) Indicate the phase-transition(s) where the cell would arrest if you add hydroxyurea.
In class, we talked about flow cytometry which allows scientists to determine what stage of the cell cycle cells are in by measuring their DNA content. Draw what the graph would look like for the mutant below at a 0-time point when there are 1000 cells total, with 5000 cells in G1, 350 cells in M and G2, and 150 cells in S phase. And then a graph of 1 hour later when the cells should have competed for mitosis:
→ loss of function of cdc25
Explain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop.
a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in?
Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase?
The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis?
As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…
Chapter 17 Solutions
GENETIC ANALYSIS: INTEGRATED - ACCESS
Ch. 17 - 17.1 Reciprocal crosses of experimental animals or...Ch. 17 - 17.2 How are some of the characteristics of the...Ch. 17 - 17.3 The human mitochondrial genome encodes...Ch. 17 - What is the evidence that transfer of DNA from the...Ch. 17 - Draw a graph depicting the relative amounts of...Ch. 17 - Prob. 6PCh. 17 - 17.7 What is the evidence that the ancient...Ch. 17 - 17.8 Outline the steps required for a gene...Ch. 17 - 17.9 Consider the phylogenetic tree presented in...Ch. 17 - You are a genetic counselor, and several members...
Ch. 17 - A mutation in Arabidopsis immutans results in the...Ch. 17 - What type or types of inheritance are consistent...Ch. 17 - You have isolated (1) a streptomycin-resistant...Ch. 17 - You have isolated two petite mutants, pet1 and...Ch. 17 - 17.15 Consider this human pedigree for a vision...Ch. 17 - A 50- year - old man has been diagnosed with MELAS...Ch. 17 - 17.17 The first person in a family to exhibit...Ch. 17 - Prob. 18PCh. 17 - 17.19 What is the most likely mode of inheritance...Ch. 17 - 17.20 In , the Russian Tsar Nicholaswas deposed,...Ch. 17 - 17.21 The dodo bird (Raphus cucullatus) lived on...Ch. 17 - Cytoplasmic male sterility (CMS) in plants has...Ch. 17 - 17.23 Wolves and coyotes can interbreed in...Ch. 17 - Prob. 24PCh. 17 - Prob. 25PCh. 17 - Most large protein complexes in mitochondria and...Ch. 17 - As described in this chapter, mothers will pass on...
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- Mitotic nondisjunction can occur, particularly in tumor cells. Assume a single nondisjunction event involving the X chromosome occurs in a cell undergoing mitosis in a human female. First, consider the daughter cell with the smaller number of chromosomes: How many total chromosomes will this cell have? How many X chromosomes will this cell have? Next, consider the daughter cell with the larger number of chromosomes: How many total chromosomes will this cell have? How many X chromosomes will this cell have?arrow_forwardDraw and label G1 and G2 stages of interphase and each stage of mitosis (in order) for a cell that has two large and two small chromosomes, 2n=4. For unreplicated chromosome draw a line ( / ) and for replicated chromosome draw an X. Since we are focusing on the DNA, you can skip drawing the nuclear membrane or spindle fibers. For simplicity, do not indicate that the chromosomes are decondensed chromatin during interphase. Mark and label a place on one of the large chromosomes with the dominant allele of the “A” gene and put the recessive allele “a” on the other homolog. Mark and label a place on one of the small chromosomes with allele “B” and put the recessive allele “b” on the other homolog.arrow_forwardIn a turtle species, a diploid cell in the G1 phase of the cell cycle contains 22 picograms of DNA (picogram is a measure of the total mass of the DNA present). How much DNA is present in a cell of the same species at prophase II of meiosis (prophase of the second meiotic division)?arrow_forward
- For below problem, consider a diploid cell that contains three pairs of chromosomes designated AA, BB, and CC. Each pair contains a maternal and a paternal member (e.g., Am and Ap). Using these designations, demonstrate your understanding of mitosis and meiosis by drawing chromatid combinations as requested. Be sure to indicate when chromatids are paired as a result of replication and/or synapsis. You may wish to use a large piece of brown manila wrapping paper or a cut-up paper grocery bag for this project and to work in partnership with another student. We recommend cooperative learning as an efficacious way to develop the skills you will need for solving the problems presented throughout this text. Question: Assume that each gamete resulting from Problem 29 fuses, in fertilization, with a normal haploid gamete. What combinations will result? What percentage of zygotes will be diploid, containing one paternal and one maternal member of each chromosome pair?arrow_forwardConsider the figure below showing how the concentration of four cyclins (comp A to comp D) vary throughout the cell cycle. Comp B Comp C Comp D Comp A G1 Phase S Phase G2 Phase Mitosis i) Why does the concentration of different cyclins vary throughout the cell cycle? ií) which of the four cyclins shown represents the G1 cyclin? What is the function of this cyclin? Concentrationarrow_forwardYou isolate a cell from a yeast species (a eukaryote) where n = 8, apply a chemical that forces chromosomes to condense, and then make a karyotype. You observe a cell with 16 DNA molecules. The stage of this cell: (A) [Select] [ Select] (B) [Select] and each chromosome is made up of [Select] [Select] (C) [Select] be G1 of the cell cycle, because at that stage the cell is O [Select] and so has [Select] and each chromosome is made up of [Select] and so has [Select] be Metaphase of Mitosis, because at that stage the cell is chromosomes and so has [Select] chromatid(s). and each chromosome is made up of [Select ] chromosomes chromatid(s). ✪ be Prophase II of Meiosis, because at that stage the cell is ↑ chromosomes ? chromatid(s),arrow_forward
- A crayfish strain became triploid while kept in a pet store. Pet owners released these crayfish into the wild, and they became an invasive species. These triploid animals have 2 different kinds of chromosomes (chromosome 1 and chromosome 2). To understand what kind of difficulties the crayfish triploid cells might have during the cell cycle you will draw: Cell is triploid with 2 different chromosomes ( 1 and 2) A) cell in G1 (assume chromosomes are condensed as they normally are in metaphase throughout the cell cycle) B) cell in G2 (assume chromosomes are condensed as they normally are in metaphase throughout the cell cycle) C) cell in Metaphase of mitosis D) cell in Metaphase I of the first meiotic division E) cell in Metaphase II of the second meiotic divisionarrow_forwardA simple diagram indicating the alterations in genetic content throughout mitosis could be prepared as follows: 2n 2n 2n duplicated 4n 2n above). Include all of the cells generated at each stage. (G1) (S phase) (G2, Prophase, Metaphase) (Anaphase) (Telophase) (Cytokinesis) prepare a similar diagram for meiosis, starting with a diploid cell in G1 (asarrow_forwardWhat are the three protein families that regulate the cell cycle? give an example for each:arrow_forward
- In the absence of Separase, how would this affect the chromosomes dynamic during mitosis? Explain in detail. *arrow_forwardDraw a diagram of the cell cycle and label the phases (G1, S, G2, M). Indicate the phase when chromosome duplication occurs.arrow_forwardillustrate and briefly describe the alignment, pairing, and disjunction ofsister chromatids during mitosis. Include the molecular complexes cohesin and shugoshin and the enzyme separase.arrow_forward
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