GENETIC ANALYSIS: INTEGRATED - ACCESS
3rd Edition
ISBN: 9780135349298
Author: Sanders
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 17, Problem 15P
Consider this human pedigree for a vision defect.
What is the most probable mode of inheritance of the disease? Identify any discrepancies between the pedigree and your proposed mode of transmission, and provide possible explanations for these exceptions.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Consider a Droscophilia fly with a genotype of Nn XqYY. The dominant allele of the sex-linked gene specifies a black body and the recessive a white body. The recessive autosomal allele specifies hairy bristles while the dominant allele specifies smooth bristles.
i)What is the ploidy of this fly?
ii) What would the sex of this fly be?
iii)What would the phenotype of this fly be with respect to these two loci?
Compare and contrast the molecular and phenotypic features of Prader-Willi and Angelman syndromes.
Ill.siven the following pedigree below, use Punnett squares for each of the following possibilities: a) X-
linked dominant, b) X-linked recessive, c) Autosomal dominant and d) Autosomal recessive in order
to determine what is the mode of transmission of this trait. Disease allele = Xª, x², A or a depending
on mode of transmission of the disease respectively. Unaffected X chromosome = X
*Homozygous unaffected/No
1
*2
carrier=Normal
II
1
*4
1
2 3
6.
7 8
a) X-linked dominant
11x12
b) X-linked recessive I 1 x1 2
c) Autosomal dominant 11x12
d) Autosomal recessive I1x12
IV.
Based on your analysis what is the mode of transmission for this disease?
O+
Chapter 17 Solutions
GENETIC ANALYSIS: INTEGRATED - ACCESS
Ch. 17 - 17.1 Reciprocal crosses of experimental animals or...Ch. 17 - 17.2 How are some of the characteristics of the...Ch. 17 - 17.3 The human mitochondrial genome encodes...Ch. 17 - What is the evidence that transfer of DNA from the...Ch. 17 - Draw a graph depicting the relative amounts of...Ch. 17 - Prob. 6PCh. 17 - 17.7 What is the evidence that the ancient...Ch. 17 - 17.8 Outline the steps required for a gene...Ch. 17 - 17.9 Consider the phylogenetic tree presented in...Ch. 17 - You are a genetic counselor, and several members...
Ch. 17 - A mutation in Arabidopsis immutans results in the...Ch. 17 - What type or types of inheritance are consistent...Ch. 17 - You have isolated (1) a streptomycin-resistant...Ch. 17 - You have isolated two petite mutants, pet1 and...Ch. 17 - 17.15 Consider this human pedigree for a vision...Ch. 17 - A 50- year - old man has been diagnosed with MELAS...Ch. 17 - 17.17 The first person in a family to exhibit...Ch. 17 - Prob. 18PCh. 17 - 17.19 What is the most likely mode of inheritance...Ch. 17 - 17.20 In , the Russian Tsar Nicholaswas deposed,...Ch. 17 - 17.21 The dodo bird (Raphus cucullatus) lived on...Ch. 17 - Cytoplasmic male sterility (CMS) in plants has...Ch. 17 - 17.23 Wolves and coyotes can interbreed in...Ch. 17 - Prob. 24PCh. 17 - Prob. 25PCh. 17 - Most large protein complexes in mitochondria and...Ch. 17 - As described in this chapter, mothers will pass on...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- We often speak of diseases such as phenylketonuria (PKU) andachondroplasia as having a genetic basis. Explain whether the followingstatements are accurate with regard to the genetic basis ofany human disease (not just PKU and achondroplasia).A. An individual must inherit two copies of a mutant allele to havedisease symptoms.B. A genetic predisposition means that an individual has inheritedone or more alleles that make it more likely that she or he willdevelop disease symptoms than other individuals in a populationwill.C. A genetic predisposition to develop a disease may be passedfrom parents to offspring.D. The genetic basis for a disease is always more important thanthe environment.arrow_forwarda. On the basis of this pedigree, what is the most likely mode of inheritance for the disease? Explain your reasoning. b. Based your answer to part a, give the most likely genotypes for all family members in the pedigree.arrow_forwardThe karyotypes shown here depict chromosomal abnormalities. Name the syndromes and if they are male or female?arrow_forward
- Describe both the primary gene or protein defect and the resulting phenotype for the following diseases a) Cystic fibrosis, b) Gaucher's diseasearrow_forwardNiemann Pick Type C disease is a recessive disorder that causes the accumulation of cholesterol and other lipids in lysosomes, ultimately affecting both the liver and the nervous system. Below are the genotypes and phenotypes of offspring of a family with a history of Niemann Pick. 7 NN ( all normal phenotype) 3 Nn (all normal phenotype) 4 nn (1 early onset dementia, 1 mid-life onset dementia, 2 late-onset dementia). From this information, Niemann-Pick disease is an example of: A) variable expressivity B) incomplete dominance C) incomplete penetrance D) variable expressivity and incomplete penetrance E) multiple allelesarrow_forwardPancreatic cancer is clearly inherited as an autosomal dominant trait in the family illustrated in Figure 23.1. Yet most cases of pancreatic cancer are sporadic, appearing as isolated cases in families with no obvious inheritance. How can a trait be strongly inherited in one family and not inherited in another?arrow_forward
- a) A woman who is type A has a daughter who is type O. Give the genotypes of both the mother and of the daughter. b) The mother claims a man who is type B is the father. Is that possible? Explain. c) The accused man can prove that both of his parents are type AB. Is it possible for him to be type B? If so, what is his genotype? d) Does the answer in part c change the answer in part b?arrow_forwardRegarding albinism, discuss some social and environmental implications of the genetic disorder.arrow_forwardExplain the following diagram. It refers to a pedigree on the disease called phenylketonuria. Briefly explain about the disease; specifically biochemical and genetic aspects. Then I interpret the pedigree. Say what type of inheritance the condition exhibitsarrow_forward
- Determine what is the most likely mode of inheritance of this disease (whether it is inherited as the result of an X-linked dominant or X-linked recessive trait). Use "A" for the allele associated with the dominant phenotype, and lowercase "a"" for the allele associated with the recessive phenotype. Write the most probable genotype for each individual based on the mode of inheritance you have determined. Show how all the partners are crossed and the expected offspring produced (You may use Punnett Square). OT I OT do IIarrow_forwardPKU is an inherited disease caused by a recessive allele. If a woman and her husband, who are both carriers (heterozygotes) for the disorder, have three children, what is the probability of each of the following? a) All three children are of normal phenotype. b) All three children have the disease. c) Any 2 of the three children have the normal phenotype.arrow_forwardA man and a woman have a child with cystic fibrosis. Neither parent has cystic fibrosis. How could this happen? a) Both parents carry the cystic fibrosis allele, and each passed that allele to their child. b) The child had a spontaneous mutation on both copies of their CFTR alleles, leading to cystic fibrosis. c) One parent gave the child two copies of the cystic fibrosis CFTR allele. c) One parent gave the child a wild type CFTR allele, and the other parent gave them a cystic fibrosis CFTR gene.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY