GENETIC ANALYSIS: INTEGRATED - ACCESS
GENETIC ANALYSIS: INTEGRATED - ACCESS
3rd Edition
ISBN: 9780135349298
Author: Sanders
Publisher: PEARSON
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Chapter 17, Problem 26P

Most large protein complexes in mitochondria and chloroplasts are composed both of proteins encoded in the organelle genome and proteins encoded in the nuclear genome. What complexities does this introduce for gene regulation (i.e., for ensuring that the appropriate relative numbers of the proteins in a complex are produced)?

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7. Progression from metaphase to anaphase in the cell cycle, and subsequent exit from anaphase, requires sequential events involving the Anaphase Promoting Complex (APC). APC is a multi- protein complex that has ubiquitin ligase activity (see pp. 611-612 in your textbook re: ubiquitin). When APC adds adds ubiquitin to a substrate protein, the protein is targeted for degradation by the proteasome. Two important substrates of APC are the proteins securin and cyclin B. Destruction of securin allows the separation of sister chromatids at the beginning of anaphase, whereas subsequent destruction of cyclin B allows cells to exit anaphase (see Figure 24-18 in your textbook). APC Cdh-1 Cdc20- Securin Mitotic cyclins Cohesin G1 Metaphase Anaphase For APC to bind specific substrates, it requires unique adaptor proteins that help it to recognize its substrates. The adaptor protein Cdc20 allows APC to recognize and ubiquitinate securin, while the adaptor Cdh-1 allows APC to recognize and…

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GENETIC ANALYSIS: INTEGRATED - ACCESS

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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY