CAMPBELL BIO TXT+MOD.MAST.BIO W ETEXT
CAMPBELL BIO TXT+MOD.MAST.BIO W ETEXT
10th Edition
ISBN: 9781323257937
Author: Reece
Publisher: PEARSON C
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Chapter 18, Problem 10TYU
Summary Introduction

Introduction: The mutations in genes that regulate cell growth either inhibiting or promoting, result in abnormal uncontrolled growth. The accumulation of these mutations leads to cancer. On the basis of regulation, the genes are categorized as proto-oncogenes and tumor-suppressor genes. Proto-oncogenes are normal growth promoting genes and their mutated forms causing tumor are oncogenes. Tumor-suppressor genes normally inhibit cell proliferation and tumor formation.

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Why does a single mutation in a proto-oncogene, turning it into an oncogene potentially lead to a cancerous phenotype, while it takes two mutations in tumor suppressor genes to lead to a cancerous phenotype?
What is the difference between a proto-oncogene and an oncogene?   a. oncogenes cause benign tumors (polyps), proto-oncogenes cause malignant tumors   b. oncogenes transform cells to hyperproliferation, proto-oncogenes have a normal cellular role   c. oncogenes have undergone post-translational modification, proto-oncogenes have not   d. oncogenes have undergone intron splicing,  proto-oncogenes have not
What role Proto-oncogenes play ?

Chapter 18 Solutions

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