Biological Science (7th Edition)
7th Edition
ISBN: 9780134678320
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Textbook Question
Chapter 18, Problem 15PIAT
What characteristic of the light-producing regulatory circuit is consistent with the idea that it may be a regulon? What characteristic of this circuit stretches the definition for a regulon?
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The allosteric regulation of ATCase by CTP is an example of:
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Negative homotropic allostery
2.
Positive homotropic allostery
3.
Negative heterotropic allostery
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Positive heterotropic allostery
The protein fragments ABS1 and ABS2 of tropomodulin were produced as fusion proteins with chitin binding domain and purified by a chitin column. Explain the principles of this type of affinity chromatography and support it with a self‐drawn figure. This is with regards to Tropomodulin/ F-Actin complex.
Researchers who study those rods cells have performed a series of experiments to better understand
this phototransduction pathway and the role of this PDE protein in patients that suffer from night
blindness. In one experiment, researchers have measured the cytosolic concentration of cGMP (cyclic-
GMP) under different light intensities (exposure = 10 min) in both the presence and the absence of the
PDE6i inhibitor.
The results are as follow: the cytosolic concentration of cGMP (cyclic-GMP) decreases as light intensity
increases, but only in the absence of the PDE6i inhibitor (see figure below).
Without PDE6i
cGMP concentration (A.U)
25
20
15-
10-
0
0
0.1
A.U (Arbitraty Unit)
0.2
0.3
Light intensity (A.U)
25
-20
-15
-10
-5
0.4
0
GMP concentration (A.U)
cGMP concentration (A.U)
25
20-
15-
10
0-
0
0.1
With PDE6i
0.2
0.3
Light intensity (A.U)
-20
C. The PDE protein is an oxidase that reduces GMP into a cGMP
D. The PDE protein is a phosphodiesterase that converts cGMP into a GMP
E. The PDE…
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