Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 18, Problem 16P
The pair
a. Given the hierarchy of gene action during Drosophila embryogenesis, what might you predict to be the result of these experiments?
b. Based on your prediction, can you predict the
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Chapter 18 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 18 - 18.1 Explain why many developmental genes encode...Ch. 18 - Bird beaks develop from an embryonic group of...Ch. 18 - 18.3 How is positional information provided along...Ch. 18 - Early development in Drosophila is atypical in...Ch. 18 - 18.5 Consider the evenskipped regulatory sequences...Ch. 18 - What is the difference between a parasegment and...Ch. 18 - Why do loss-of-function mutations in Hox genes...Ch. 18 - 18.8 Compare and contrast the specification of...Ch. 18 - Prob. 9PCh. 18 - Ablation of the anchor cell in wild type C....
Ch. 18 - 18.11 In gain-of-function and. elegans mutants,...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - 18.14 Given that maternal Bicoid activates the...Ch. 18 - What phenotypes do you expect in flies homozygous...Ch. 18 - The pair rule gene fushitarazu is expressed in...Ch. 18 - 18.17 In contrast to Drosophila, some insects...Ch. 18 - Prob. 18PCh. 18 - 18.19 You are traveling in the Netherlands and...Ch. 18 - 19.20 A powerful approach to identifying genes of...Ch. 18 - The Hoxd 913 genes are thought to specify digit...Ch. 18 - Three-spined stickleback fish live in lakes formed...Ch. 18 - The flowering jungle plant Lacandoniaschismatica,...Ch. 18 - 18.24 Homeotic genes are thought to regulate each...Ch. 18 - Prob. 25PCh. 18 - Basidiomycota is a monophyletic group of fungi...Ch. 18 - Prob. 27PCh. 18 - In C. elegans there are two sexes: hermaphrodite...Ch. 18 - In Drosophila, recessive mutations in the...
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- a. The eyeless gene is required for eye formation in Drosophila. It encodes a homeodomain. What would you predict about the biochemical function of the Eyeless protein?b. Where would you predict that the eyeless gene is expressed in development? How would you test your prediction? c. The Small eye and Aniridia genes of mice and humans, respectively, encode proteins with very strong sequence similarity to the fly Eyeless protein, and they are named for their effects on eye development. Devise one test to examine whether the mouse and human genes are functionally equivalent to the fly eyeless gene.arrow_forwardExplain the functional roles of maternal-effect genes, gap genes, pair-rule genes, and segment-polarity genes in Drosophila development.arrow_forwardDiscuss how the anterior portion of the anteroposterior axis is established in Drosophila. What aspects of oogenesis are critical in establishing this axis? What do you think would happen if the bicoid mRNA was not trapped at the anterior end but instead diffused freely throughout the oocyte?arrow_forward
- Why is it that mutations in bicoid and nanos exhibit genetic maternal effect in Drosophila (a mutation in the maternal parent produces a phenotype that shows up in the offspring), but mutations in runt and gooseberry do not?arrow_forwardIn humans, dosage compensation is accomplished by: inactivating one X chromosome in female somatic cells inactivating one homolog from each homologous pair of chromosomes in female somatic cells inactivating the Y chromosome in male somatic cells increasing gene expression from the X chromosome in male somatic cellarrow_forwardThe easily observed external structures in insects, such as different pairs of legs, antennae, and wings form from imaginal discs. a.) How is the identity of the different Drosophila imaginal discs established in the embryo—for example, how is it determined whether a disc will form a wing, a leg, or some other structure? b.) Dominant mutants in the gene Antennapedia result in fore legs forming in the location where antennae are expected. How does this mutant phenotype illustrate your response to Part a?arrow_forward
- The locations of six deletions have been mapped to a Drosophila chromosome, as shown in the following deletion map. Recessive mutations a, b, c, d, e, and f are known to be located in the same region as the deletions, but the order of the mutations on the chromosome is not known. (refer image for contination )arrow_forwardIn flies, the gap gene kruppel is expressed in a broad band in the middle of the embryo with giant expressed as its anterior border and knirps at its posterior border. How is the expression of kruppel limited to this band in the embryo? Describe the spatial regulation of the kruppel gene.arrow_forwardWhat would be the most likely effect of inhibiting the translation of hunchback mRNA throughout a Drosophila embryo?arrow_forward
- What is the signaling pathway that mediates the organizing activity of the A/P organizer in the Drosophila wing disc? Describe two experiments that suggest this pathway functions to organize pattern and promote growth along the anterior/posterior axis of wing imaginal discs.arrow_forwardThe locations of six deletions have been mapped to a Drosophila chromosome, as shown in the following deletion map. Recessive mutations a, b, c, d, e, and f are known to be located in the same region as the deletions, but the order of the mutations on the chromosome is not known.arrow_forwardResearchers have exploited Minute mutations in orderto study the phenotypes associated with recessive lethal mutations (l−) that decrease the rate of cell divisionand thus make only very tiny homozygous mutant clones that are difficult to analyze. Many differentstrains of Drosophila carry dominant loss-of-functionMinute (M) mutations in a variety of genes encodingribosomal protein subunits. The M genes are haploinsufficient; flies with only one wild-type M+ gene copyhave a slower pace of cell division, and thus prolongeddevelopment and subtle morphological abnormalities.To circumvent the tiny clone problem, researchersgenerate GFP-marked homozygous l−/ l− clones thatare also M+/ M+, in flies that are l−/ l+ and M−/ M+.The loss of the Minute mutation only in cells withinthe clone gives the l−/ l− cells a growth advantageover their neighbors, enabling the mutant clone togrow large enough to study. Diagram chromosomesthat could be used to generate such clonesarrow_forward
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Embryology | Fertilization, Cleavage, Blastulation; Author: Ninja Nerd;https://www.youtube.com/watch?v=8-KF0rnhKTU;License: Standard YouTube License, CC-BY