Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 18, Problem 17P
In contrast to Drosophila, some insects (e.g., centipedes) have legs on almost every segment posterior to the head. Based on your knowledge of Drosophila, propose a genetic explanation for this
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Chapter 18 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 18 - 18.1 Explain why many developmental genes encode...Ch. 18 - Bird beaks develop from an embryonic group of...Ch. 18 - 18.3 How is positional information provided along...Ch. 18 - Early development in Drosophila is atypical in...Ch. 18 - 18.5 Consider the evenskipped regulatory sequences...Ch. 18 - What is the difference between a parasegment and...Ch. 18 - Why do loss-of-function mutations in Hox genes...Ch. 18 - 18.8 Compare and contrast the specification of...Ch. 18 - Prob. 9PCh. 18 - Ablation of the anchor cell in wild type C....
Ch. 18 - 18.11 In gain-of-function and. elegans mutants,...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - 18.14 Given that maternal Bicoid activates the...Ch. 18 - What phenotypes do you expect in flies homozygous...Ch. 18 - The pair rule gene fushitarazu is expressed in...Ch. 18 - 18.17 In contrast to Drosophila, some insects...Ch. 18 - Prob. 18PCh. 18 - 18.19 You are traveling in the Netherlands and...Ch. 18 - 19.20 A powerful approach to identifying genes of...Ch. 18 - The Hoxd 913 genes are thought to specify digit...Ch. 18 - Three-spined stickleback fish live in lakes formed...Ch. 18 - The flowering jungle plant Lacandoniaschismatica,...Ch. 18 - 18.24 Homeotic genes are thought to regulate each...Ch. 18 - Prob. 25PCh. 18 - Basidiomycota is a monophyletic group of fungi...Ch. 18 - Prob. 27PCh. 18 - In C. elegans there are two sexes: hermaphrodite...Ch. 18 - In Drosophila, recessive mutations in the...
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- Figure 13-7 illustrates the expression of the Ultrabithorax(Ubx) Hox protein in developing flight appendages.What is the relationship between where the protein isexpressed and the phenotype resulting from the loss ofits expression (shown in Figure 13-1)?arrow_forwardExposing C. elegans to an RNAi molecule homologous to a non-protein-coding RNA gene resulted in the worms’ inability to respond to touch. What predictions could you make about the function of that gene in development?arrow_forwardWhat is positional information? Discuss three different ways that cells obtain positional information. Which of these three ways do you think is the most important for the formation of a segmented body pattern in Drosophila?arrow_forward
- “In the early Drosophila embryo, the establishment of different body regionor tissues along, on the one hand, the anteroposterior axis and, on theother, the dorsoventral axis are initiated by clues provided by the egg’smother; however the nature of those signals and the way in which theyoperate is completely different”. Discuss whether this statement is correct.arrow_forwardHomeotic genes(A) encode transcription factors that control the expression ofgenes responsible for specific anatomical structures.(B) are found only in Drosophila and other arthropods.(C) are the only genes that contain the homeobox domain.(D) encode proteins that form anatomical structures in the fly.arrow_forwardWhat phenotypes do you think a homozygous tra1hsn animal with a gain of function mutation in the Egl1 would have.arrow_forward
- In flies, the gap gene kruppel is expressed in a broad band in the middle of the embryo with giant expressed as its anterior border and knirps at its posterior border. How is the expression of kruppel limited to this band in the embryo? Describe the spatial regulation of the kruppel gene.arrow_forwardThe three homeodomain proteins Abd-B, Abd-A, andUbx are encoded by genes within the Bithorax complexof Drosophila. In wild-type embryos, the Abd-B gene isexpressed in the posterior abdominal segments, Abd-Ain the middle abdominal segments, and Ubx in the anterior abdominal and posterior thoracic segments. Whenthe Abd-B gene is deleted, Abd-A is expressed in both themiddle and the posterior abdominal segments. WhenAbd-A is deleted, Ubx is expressed in the posterior thoraxand in the anterior and middle abdominal segments.When Ubx is deleted, the patterns of Abd-A and Abd-Bexpression are unchanged from wild type. When bothAbd-A and Abd-B are deleted, Ubx is expressed in all segments from the posterior thorax to the posterior end ofthe embryo. Explain these observations, taking into consideration the fact that the gap genes control the initialexpression patterns of the homeotic genesarrow_forwarda. Explain how you could use worms transformedwith myo-2::GFP to find mutations that disrupt thestructure of the pharynx. How would the presenceof the transgene facilitate the mutant screen?b. Nematodes homozygous for loss-of-function mutations in a gene called pha-4 have no detectablepharyngeal structures. How could you use myo2::GFP to determine if pha-4 is a master regulatory gene that directs development of the pharynxin a manner similar to the way Pax-6/eyeless controls eye development?arrow_forward
- What is the signaling pathway that mediates the organizing activity of the A/P organizer in the Drosophila wing disc? Describe two experiments that suggest this pathway functions to organize pattern and promote growth along the anterior/posterior axis of wing imaginal discs.arrow_forwardCompare and contrast the experimental advantages and disadvantages of Drosophila, C. elegans, mammals, and Arabidopsis.arrow_forwardPropose a hypothesis that could explain the following observation. A graduate student performing studies on mutations in drosophila (fruit flies) discovered a strain of flies with a silent mutation in the gene controlling the shape of the wings. Further investigation has shown that this mutation is lethal in flies who are homozygote. Flies that are homozygote wild type or heterozygote can develop and are able to survive.arrow_forward
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