a. To determine: The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells. Introduction: The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

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Answer 1

Question

Chapter 18, Problem 17P

Summary Introduction

a.

To determine:

The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

Introduction:

The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

Summary Introduction

b.

To determine:

The way by which transgenic mouse can be produced for the overexpression of myc and controlled expression of cre transgene.

Introduction:

Various scientists hypothesise that the overexpression of myc protein in the specialised B cells results in the formation of lymphoma in organisms.

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The Bcl-2 protein was initially discovered via its ability to contribute to progression of B-cells to a cancerous "lymphoma" phenotype. 1) Define the mutation that was associated with the change in Bcl-2 in these cells. 2) Is Bcl-2 an oncogene or a tumor suppressor gene? 3) Define the role of Bcl-2 in normal cellular function and how this changed in Bcl-2 associated lymphoma.

Describe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the particular mechanism for generating oncogenic MYC result in a lymphoma rather than another type of cancer? Describe another mechanism for generating oncogenic MYC.

D) The level of carbon dioxide increases with the level of available oxygen. 60) The TPS3 gene provides instructions for making a protein called tumor protein p53. Known as the guardlan of the genome, this protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing t0o fast or in an uncontrolled way. The p53 protein is located in the nucleus of cells throughout the body, where it attaches directly to DNA and plays a critical role in determining whether the DNA will be repaired or the damaged cell will self- destruct (undergo apoptosis). If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. Suppose chromosomes in a skin cell are damaged by ultraviolet radiation. If the damaged genes do not affect p53, which choice correctly predict if the cell will become cancerous and why? No, the cell will not…

Answer 2

Question

Chapter 18, Problem 17P

Summary Introduction

a.

To determine:

The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

Introduction:

The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

Summary Introduction

b.

To determine:

The way by which transgenic mouse can be produced for the overexpression of myc and controlled expression of cre transgene.

Introduction:

Various scientists hypothesise that the overexpression of myc protein in the specialised B cells results in the formation of lymphoma in organisms.

Expert Solution & Answer

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Answer 3

Question

Chapter 18, Problem 17P

Summary Introduction

a.

To determine:

The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

Introduction:

The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

Summary Introduction

b.

To determine:

The way by which transgenic mouse can be produced for the overexpression of myc and controlled expression of cre transgene.

Introduction:

Various scientists hypothesise that the overexpression of myc protein in the specialised B cells results in the formation of lymphoma in organisms.

Expert Solution & Answer

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Answer 4

Question

Chapter 18, Problem 17P

Summary Introduction

a.

To determine:

The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

Introduction:

The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

Summary Introduction

b.

To determine:

The way by which transgenic mouse can be produced for the overexpression of myc and controlled expression of cre transgene.

Introduction:

Various scientists hypothesise that the overexpression of myc protein in the specialised B cells results in the formation of lymphoma in organisms.

Expert Solution & Answer

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Answer 5

Chapter 18, Problem 17P

Summary Introduction

a.

To determine:

The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

Introduction:

The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

Summary Introduction

b.

To determine:

The way by which transgenic mouse can be produced for the overexpression of myc and controlled expression of cre transgene.

Introduction:

Various scientists hypothesise that the overexpression of myc protein in the specialised B cells results in the formation of lymphoma in organisms.

Answer 6

Chapter 18, Problem 17P

Summary Introduction

a.

To determine:

The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

Introduction:

The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

Answer 7

Chapter 18, Problem 17P

Summary Introduction

a.

To determine:

The ways by which pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

Introduction:

The tumour cells obtained from the patients of Burkitt lymphoma possess the myc gene that appears very close to the breakpoint of the reciprocal type of translocation.

Answer 8

Summary Introduction

b.

To determine:

The way by which transgenic mouse can be produced for the overexpression of myc and controlled expression of cre transgene.

Introduction:

Various scientists hypothesise that the overexpression of myc protein in the specialised B cells results in the formation of lymphoma in organisms.

Answer 9

Summary Introduction

b.

To determine:

The way by which transgenic mouse can be produced for the overexpression of myc and controlled expression of cre transgene.

Introduction:

Various scientists hypothesise that the overexpression of myc protein in the specialised B cells results in the formation of lymphoma in organisms.

Answer 10

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Answer 11

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Answer 12

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Answer 13

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Solution Summary: The author explains how pronuclear injection generated mice can be used to test the hypothesis of overexpression of myc in the B cells.

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