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Interpretation:
To explain why a methoxy group (CH3O) increases the rate of electrophilic aromatic substitution, but decreases the rate of nucleophilic aromatic substitution
Concept introduction:
The characteristic reaction of benzene is known as electrophilic aromatic substitution reaction-a hydrogen atom is replaced by an electrophile. Because of benzene has six pi electrons that delocalized in six p-orbitals that overlap above and below the plane of the benzene ring. These loosely held pi-electrons make the benzene ring electron rich, and so it reacts with electrophiles. Moreover because of benzene's six pi electrons satisfy Huckel's rule, benzene is especially stable ring. Reactions that keep the aromatic ring intact are therefore favored. A substituent in the benzene can affect the electrophilic aromatic substitution.
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Chapter 18 Solutions
Organic Chemistry-Package(Custom)
- When propene reacts with gaseous hydrogen bromide, HBr, two products, 1-bromopropane and 2-bromopropane are formed. The reaction is a two-step process in which the electrophilic attack occurs in the first step. Identify the electrophile in this reaction Draw a diagram showing the first step of the reaction that leads to the production of 2-bromopropane.arrow_forwardDefine Reaction as a Nucleophile ?arrow_forwardConsider the following nucleophilic substitution reaction. The compound listed above the arrow is the solvent for the reaction. If nothing is listed over the arrow, then the nucleophile is also the solvent for the reaction. I acetone + HSarrow_forward
- Define nucleophilic aromatic substitution ?arrow_forwardWhat explains why many aldehydes and ketones can undergo self-condensation reactions in basic conditions? The alpha carbon can lose a proton and act like a nucleophile and the carbonyl carbon is an electrophile. The alpha carbon can gain a proton and act like an electrophile and the carbonyl carbon is a nucleophile. The oxygen of the carbonyl group can attack the carbon of the carbonyl group. Only esters can undergo self-condensation reactions.arrow_forwardExplain why methyl trifluoroacetate, CF3CO2CH3, is more reactive than methyl acetate, CH3CO2CH3, in nucleophilic acyl substitution reactions.arrow_forward
- The Wittig sequence includes this/these reaction step/s. O nucleophilic substitution of a phosphine on an alkyl halide O acid-base reaction removing a hydrogen from the carbon next to the phosphonium group to form an ylide O the aldehyde or ketone combines with the ylide to form an oxaphosphetane O the oxaphosphetane breaks down to form the alkene and a phosphine oxide O all of the above O none of the abovearrow_forwardWhat explains why many aldehydes and ketones can undergo self- condensation reactions in basic conditions? The alpha carbon can lose a proton and act like a nucleophile and the carbonyl carbon a an electrophile O The alpha carbon can gain a proton and act like an electrophile and the carbonyl carbon is a nucleophile O The oxygen of the carbonyl group can attack the carbon of the carbonyl group Only esters can undergo self-condensation reactionsarrow_forwardDefine ambident nucleophile ?arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning
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