(a)
Interpretation: The acid chloride which is needed to prepare the given
Concept introduction: The Friedel-Craft acylation is a type of electrophilic substitution reaction.
(b)
Interpretation: The acid chloride which is needed to prepare the given ketones from benzene using a Friedel-Craft acylation is to be predicted.
Concept introduction: The Friedel-Craft acylation is a type of electrophilic substitution reaction.
(c)
Interpretation: The acid chloride which is needed to prepare the given ketones from benzene using a Friedel-Craft acylation is to be predicted.
Concept introduction: The Friedel-Craft acylation is a type of electrophilic substitution reaction.
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ORGANIC CHEMISTRY-MOLYMOD PACKAGE
- When trichloroacetaldehyde is dissolved in water, almost all of it is converted to the hydrate. Chloral hydrate, the product of the reaction, is a sedative that can be lethal. A cocktail laced with it is known—in detective novels, at least—as a “Mickey Finn.” Explain why an aqueous solution of trichloroacetaldehyde is almost all hydrate.arrow_forwardWhen trichloroacetaldehyde is dissolved in water, almost all of it is converted to the hydrate. Chloral hydrate, the product of the reaction, is a sedative that can be lethal. A cocktail laced with it is known—in detective novels,at least—as a “Mickey Finn.” Explain why an aqueous solution of trichloroacetaldehyde is almost all hydrate.arrow_forwardWhat product is formed when A is treated with Grubbs catalyst underhigh-dilution conditions? This reaction was a key step in the synthesis ofstemoamide, the naturally occurring amide described in the opening paragraph.arrow_forward
- Explain the following observation. Pyridine is a less weak base than pyrol.arrow_forwardExplain the reaction for the formation of acetal and hemiacetal. Explain why N,N-disubstituted amide is less acidic than ester. Why only methyl ketone do undergoes haloform reaction. LDA is the base of choice for carbonyl compound to completely convert into enolate. Why?arrow_forwardDraw a stepwise mechanism for the conversion of lactone A to ester Busing HCl in ethanol. B is converted in one step to ethyl chrysanthemate,a useful intermediate in the synthesis of a variety of pyrethrins, naturally occurring insecticides with three-membered rings that are isolated fromchrysanthemumsarrow_forward
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- One step in the synthesis of the antihistamine fexofenadine involves acid-catalyzed hydration of the triple bond in A. Draw a stepwise mechanism for this reaction and explain why only ketone B is formed.arrow_forwardAlthough codeine occurs in low concentration in the opium poppy, most of the codeine used in medicine is prepared from morphine (the principal component of opium) by the following reaction. Explain why selective methylation occurs at only one OH in morphine to give codeine. Codeine is a less potent and less addictive analgesic than morphine.arrow_forwardAcid hydrolysis of esters produces____ and____?arrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning