Concept explainers
(a)
To determine: (a) The role of fasting in the experiment is to be determined. (b) Causes of high level of ammonia in the experiment group and the reason for the absence of arginine which leads to ammonia toxicity. Also determine the reason that arginine is an essential amino acid in cats. (c) The reason that ornithine is substituted for arginine.
Introduction:
In an experiment carried out some years ago, cats were fasted overnight and then given a single meal having all amino acids expect arginine. The ammonia levels in blood increased from a usual level of
(b)
To determine: The causes that led to increase in the level of ammonia in the experiment group. The reason that arginine deficiency leads to ammonia toxicity. Also identify whether arginine is an essential amino acid in cats or not. Give reason.
Introduction:
The mitochondrial and cytosolic enzymes in the urea cycle are clustered. The citrulline transported out of mitochondria is not diluted but is passed to the active site of argininosuccinate synthetase directly.
(c)
To determine: The reason that ornithine be substituted for arginine.
Introduction:
To initiate the urea cycle, ornithine is transported into the mitochondria. This channeling between enzymes includes argininosuccinate, arginine, and ornithine.
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