A synthesis for safrole from catechol is to be shown. Concept introduction: The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl 3 , the allyl group gets introduced into the benzene ring. To give: A synthesis for safrole from catechol.

Question

Propose a synthesis of the anti-inflammatory drug Fenclorac from phenylcyclohexane.

Answer 1

Question

Chapter 18.SE, Problem 60GP

Interpretation Introduction

Interpretation:

A synthesis for safrole from catechol is to be shown.

Concept introduction:

The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl₃, the allyl group gets introduced into the benzene ring.

To give:

A synthesis for safrole from catechol.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Students have asked these similar questions

Propose a synthesis of the anti-inflammatory drug Fenclorac from phenylcyclohexane.

3,5-Dibromo-4-hydroxybenzenesulfonic acid is used as a disinfectant. Propose a synthesis of this compound from phenol.

Propose a synthesis of the topical anesthetic cyclomethycaine from 4-hydroxybenzoic acid, 2-methylpiperidine, and any other necessary reagents. HN' + HO. НО Cyclomethycaine 4-Hydroxybenzoic acid 2-Methylpiperidine

Answer 2

Question

Chapter 18.SE, Problem 60GP

Interpretation Introduction

Interpretation:

A synthesis for safrole from catechol is to be shown.

Concept introduction:

The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl₃, the allyl group gets introduced into the benzene ring.

To give:

A synthesis for safrole from catechol.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 3

Question

Chapter 18.SE, Problem 60GP

Interpretation Introduction

Interpretation:

A synthesis for safrole from catechol is to be shown.

Concept introduction:

The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl₃, the allyl group gets introduced into the benzene ring.

To give:

A synthesis for safrole from catechol.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 4

Question

Chapter 18.SE, Problem 60GP

Interpretation Introduction

Interpretation:

A synthesis for safrole from catechol is to be shown.

Concept introduction:

The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl₃, the allyl group gets introduced into the benzene ring.

To give:

A synthesis for safrole from catechol.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 5

Chapter 18.SE, Problem 60GP

Interpretation Introduction

Interpretation:

A synthesis for safrole from catechol is to be shown.

Concept introduction:

The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl₃, the allyl group gets introduced into the benzene ring.

To give:

A synthesis for safrole from catechol.

Answer 6

Chapter 18.SE, Problem 60GP

Interpretation Introduction

Interpretation:

A synthesis for safrole from catechol is to be shown.

Concept introduction:

The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl₃, the allyl group gets introduced into the benzene ring.

To give:

A synthesis for safrole from catechol.

Answer 7

Chapter 18.SE, Problem 60GP

Interpretation Introduction

Interpretation:

A synthesis for safrole from catechol is to be shown.

Concept introduction:

The requirement is a to convert an o-dihydroxy group to an epoxide and to introduce an allyl group para to one hydroxyl group and meta to another hydroxyl group. The epoxide ring is formed when the dihydroxy phenol is first treated with NaH and then with methylene bromide. When the epoxide is treated with allyl chloride in the presence of AlCl₃, the allyl group gets introduced into the benzene ring.

To give:

A synthesis for safrole from catechol.

Answer 8

Expert Solution & Answer

Answer 9

Expert Solution & Answer

Answer 10

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 11

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 12

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 13

Trending nowThis is a popular solution!

Answer 14

Trending nowThis is a popular solution!

Answer 15

Trending nowThis is a popular solution!

Answer 16

Trending now

Answer 17

This is a popular solution!

Answer 18

See solution

Check out sample textbook solution

Answer 19

Ch. 18.1 - Name the following ethers:Ch. 18.2 - Why do you suppose only symmetrical ethers are...Ch. 18.2 - How would you prepare the following ethers using a...Ch. 18.2 - Review the mechanism of oxymercuration shown in...Ch. 18.2 - How would you prepare the following ethers? Use...Ch. 18.2 - Prob. 6P Ch. 18.3 - Prob. 7P Ch. 18.3 - Write the mechanism of the acid-induced cleavage...Ch. 18.3 - Why are HI and HBr more effective than HCl in...Ch. 18.4 - What product would you expect from Claisen...

Solution Summary: The author explains a method to synthesize safrole from catechol by converting o-dihydroxy group to an epoxide and introducing allyl group para to one hydroxyl

Concept explainers

Chapter 18 Solutions