BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
9th Edition
ISBN: 9781319425784
Author: BERG
Publisher: Macmillan Higher Education
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Question
Chapter 2, Problem 10P
Interpretation Introduction
Interpretation:
The pH value at which a solution of the given amino acid would have no net charge should be indicated.
Concept introduction:
The ionization of an amino acid depends on the pH. In acidic pH both amino group and carboxylate group are protonated. When pH increases, the
The isoelectric point is the pH at which, a molecule does not have any net charge. And pI can be calculated using following formula
pI − isoelectric point.
Ka1 and Ka2 − dissociation constant of alpha amino group and alpha carboxylic group.
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V-A. Which of the following amino acids will elute first in a cation-exchange column using a buffer at pH 7?
1. Asp or Lys
2. Arg or Met
3. Gly or Val
4. Ser or Ala
Peptides.
1. Draw the peptide Ala-Glu-Gly-Lys, as it would occur at physiological pH = 7.4.
The R groups of Ala and Gly are not acidic or basic, therefore do not have a pka and the charge
on these R groups is therefore independent of pH. Glu is acidic and Lys is basic, therefore the
charge on these amino acids is pH dependent. The pKas are shown below.
pKa
N-term = 9.0
C-term = 3.5
Glu4.1
Lys = 10.5
2. Draw a circle around the peptide bonds.
3. Label the C-terminus and the N-terminus.
4. What is the overall charge on the peptide at pH 7.4?
Modified true or false. Write the correct answer if the underlined word is false.
Chapter 2 Solutions
BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37P
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