BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
9th Edition
ISBN: 9781319425784
Author: BERG
Publisher: Macmillan Higher Education
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Chapter 2, Problem 11P
Interpretation Introduction
Interpretation:
The graph of concentration versus pH for histidine should be determined and the structures of each individual species should be drawn.
Concept introduction:
The ionization of an amino acid depends on the pH. In acidic pH both amino group and carboxylate group are protonated. When pH increases, the
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01
Description
Please draw the structure of the 19 L-a-amino acids and proline in
any form, as you prefer. You may want to use a letter-size sheet or
larger, it's up to you.
Guiding principle: You want to understand the differences among
amino acids. Although you may want to only draw the R-group it's
preferable to draw it along with the rest of the molecule (i.e., the
Ca, the amino group and the carboxyl group).
Here are some examples (your drawings should not limited to the
following styles):
NH₂
OH
Alanine
H
H
O
OH
Proline
lysine
alarmy stock płwłos
Tryptophan
OH
COOH
|
H₂N-C-H
CH₂
Phenylalanine
arginine
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Chapter 2 Solutions
BIOCHEMISTRY (LOOSELEAF)-W/ACCESS
Ch. 2 - Prob. 1PCh. 2 - Prob. 2PCh. 2 - Prob. 3PCh. 2 - Prob. 4PCh. 2 - Prob. 5PCh. 2 - Prob. 6PCh. 2 - Prob. 7PCh. 2 - Prob. 8PCh. 2 - Prob. 9PCh. 2 - Prob. 10P
Ch. 2 - Prob. 11PCh. 2 - Prob. 12PCh. 2 - Prob. 13PCh. 2 - Prob. 14PCh. 2 - Prob. 15PCh. 2 - Prob. 16PCh. 2 - Prob. 17PCh. 2 - Prob. 18PCh. 2 - Prob. 19PCh. 2 - Prob. 20PCh. 2 - Prob. 21PCh. 2 - Prob. 22PCh. 2 - Prob. 23PCh. 2 - Prob. 24PCh. 2 - Prob. 25PCh. 2 - Prob. 26PCh. 2 - Prob. 27PCh. 2 - Prob. 28PCh. 2 - Prob. 29PCh. 2 - Prob. 30PCh. 2 - Prob. 31PCh. 2 - Prob. 32PCh. 2 - Prob. 33PCh. 2 - Prob. 34PCh. 2 - Prob. 35PCh. 2 - Prob. 36PCh. 2 - Prob. 37P
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- A. Write the structure of the following peptide at pH 5.0 and calculate its net charge at this pH. Asp-His-Tyr-Arg-Lys-Leu-Thr-Gln. Based on the pKa value of the ionizable groups. B. A polypeptide consisting only of L-glutamate residues (poly-L-glutamate) may have a random coil or helical structure depending on pH. Explain this behavior by indicating at what pH values the helical structure will be favored.arrow_forwarda. Suppose that you have the peptide Ala-Gly-Tyr-His-Leu and you treat it with FDNB and then 6M HCl. Draw the structures of all the products that you will have in solution (assume all reactions to go to completion).arrow_forwardUsing Fig. as a guide, draw the complete structure of a nucleoside triphosphate before and after it becomes incorporated into a polynucleotide chain. Draw the structure that would result if the newly formed phosphodiester bond were hydrolyzed.arrow_forward
- Peptides. 1. Draw the peptide Ala-Glu-Gly-Lys, as it would occur at physiological pH = 7.4. The R groups of Ala and Gly are not acidic or basic, therefore do not have a pka and the charge on these R groups is therefore independent of pH. Glu is acidic and Lys is basic, therefore the charge on these amino acids is pH dependent. The pKas are shown below. pKa N-term = 9.0 C-term = 3.5 Glu4.1 Lys = 10.5 2. Draw a circle around the peptide bonds. 3. Label the C-terminus and the N-terminus. 4. What is the overall charge on the peptide at pH 7.4?arrow_forwardAsp-Gly-Lys-Glu-Ile-Phe Draw its full chemical structure as it would exist at pH = 7.0. Draw an arrow pointing to each peptide bond. Identify the net charge of the peptide and briefly explain how you arrived at this answer.arrow_forwardR V. Phospholipids are the main structural lipids that comprise cellular and organellar membranes. One abundant phospholipid in bacterial cell membranes is phosphatidylethanolamine (PE), which has a generic structure shown on the right. Note that R1 R and R2 are representative alkyl chains of attached fatty acids, each having about 16 – 20 carbon atoms. a) The overall net charge in one PE molecule is: -2 -1 0 +1 +2 CH₂ Phosphatidylethanolamine (PE) -CH H₂C. b) The glycerophosphate backbone in PE is a: D-enantiomer c) The fatty acids are attached to PE via which type of bond? amine L-enantiomer racemic NH3 amide ester ether d) Draw the commonly used cartoon representation of one phospholipid molecule. Label the hydrophilic and hydrophobic parts.arrow_forward
- Do not give handwriting solution.arrow_forwardConsider each dipeptide. Part: 0/4 Part 1 of 4 N—C—COO བཙས་མའི་ཡའི་ཡ[ཡ་སྦ་ Identify the amino acid(s) present in this structure. Check all that apply. ☐ leucine ☐ phenylalanine ☐ tyrosine ☐ valine ☐ methionine ☐ glutamine ☐ alanine ☐ threonine ☐ serine ☐ cysteine ☐ glycine ☐ isoleucine ☐ asparaginearrow_forwardK₁ = α [H+][A-] [HA] [A-] pH = pK+log [HA] 1-1 The Amino acid Arginine ionizes according to the scheme below. Calculate the isoelectric point of Arginine and the average charge on arginine when pH = 9.2. NH2 H C=N NH pka-2.17 -H' NH2 H C=N H NH PK-8.99 -H +H* H (CH2)3 H-N-C-COOH | H H +H* H (CH2)3 H-N-C-coo- H H Ans: 10.75; +0.38 NH2 NH2 H C=N C=N-H H NH PK-12.5 -H NH | +H* (CH2)3 H₂N-C-COO- | H III (CH2)3 H₂N-C COO- H IVarrow_forward
- Macmillan Learning The graphs show a titration curve for the amino acid histidine. Label the fist curve with the major histidine species at each position. One histidine species will not be used. Label the second curve with the pKå values for the histidine functional groups and the isoelectric point (pI) of histidine. 14 12 10 8 HH pH 6 His [His] = [His] 2 His²- [His² +] = [His*] 0 0.0 0.5 1.0 Incorrect Answer 1.5 [OH-] (equivalents) Hisº His [His] = [His] 2.0 2.5 3.0 His² + Answer Bankarrow_forwardSuppose you have a solution of a protein, which contains a specific Tyr residue that has an actual (measured) pKa of 8.8. The protein binds a ligand by several noncovalent interactions, one of which is a hydrogen bond in which the Tyr phenolic hydroxyl group must serve as a hydrogen bond donor. Calculate the percentage of the protein molecules in which that tyrosyl residue's phenolic hydroxyl group could serve as a hydrogen bond donor at pH 8.5arrow_forwardMacmillan Learning The graphs show a titration curve for the amino acid histidine. Label the fist curve with the major histidine species at each position. One histidine species will not be used. Label the second curve with the pKå values for the histidine functional groups and the isoelectric point (pI) of histidine. 14 12 10 pH 6 8 4 His²+ 2 His+ 0 0.0 0.5 1.0 Incorrect Answer His²- [His²+] = [His*] 1.5 [OH-] (equivalents) Hisº His [His]=[His] 2.0 2.5 3.0 Answer Bank [His+] = [His]arrow_forward
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