Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 2, Problem 49P
Go to the OMIM website (http://www.ncbi.nlm.nih.gov/ omim) and locate the Search button at the top of the page. Use the Search function to look up, one by one, the following three human hereditary diseases that are relatively common in certain populations: “Tay–Sachs disease” (select OMIM number 272800 from the search results list); “cystic fibrosis” (select OMIM number 602421 from the search results list); and “sickle cell anemia” (select OMIM 603903 from the search results list). For each of these diseases, look through the information and provide the following details:
a. On which chromosome is the gene for the disease located?
b. What gene is mutated in the disease?
c. Briefly describe the disease.
d. In which population(s) does the disease most commonly occur?
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Sickle cell anemia is caused by an individual carrying two recessive copies of the hemoglobin gene (hemoglobin gene is labeled Hb, and the recessive version is Hbs). Thus, to have sickle cell anemia, a person must have the genotype HbSHbS. A person that is HbAHbA carries two copies of the normal hemoglobin gene and does not have sickle cell anemia. A person that is heterozygous (HbAHbS) produces enough normal hemoglobin to not have sickle cell anemia but is also resistant to malaria. People that are heterozygous are called “carriers” because they carry the recessive allele but do not express the recessive phenotype.
a. A couple are both resistant to malaria but do not have sickle cell anemia. Draw a Punnett square to represent this cross.
b. What is the probability that the couple has three children where one child does not have a recessive allele, one child is resistant to malaria and does not have sickle cell anemia, and one child has sickle cell anemia?
If a mother with sickle-cell anemia and a father with the sickle-cell trait havechildren, calculate the percentages of each genotype and phenotype of the offspring from the Punnett square.
Click on the link: https://www.dailymail.co.uk/news/article-4168946/Mum-world-s-black-woman-two-white-babies.html#ixzz4hvs1FUeM.Links to an external site.
This case explores how skin color is inherited in humans, presented in the story of Catherine and Richard Howarth whose children are surprisingly light skinned compared to their Nigerian mother.
Based on what you have learned about polygenic inheritance, explain how Richard and Catherine Howarth were able to produce light-skinned babies. Are the odds indeed 1 in a million? Include possible genotypes of the couple and their children to support your argument.
Chapter 2 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 2 -
1. Compare and contrast the following terms:
a....Ch. 2 - For the cross , what is the expected genotype...Ch. 2 - 37. Galactosemia is an autosomal recessive...Ch. 2 - In mice, black coat color is dominant to white...Ch. 2 - Two parents plan to have three children. What is...Ch. 2 - Consider the cross AaBbCCAABbCc. a. How many...Ch. 2 - If a chi-square test produces a chi-square value...Ch. 2 -
8. Determine whether the statements below are...Ch. 2 - In the datura plant, purple flower color is...Ch. 2 - 10. The dorsal pigment pattern of frogs can be...
Ch. 2 - 11. Black skin color is dominant to pink skin...Ch. 2 - A male mouse with brown fur color is mated to two...Ch. 2 - 13. Figure 2.12 shows the results of Mendel’s...Ch. 2 - 14. An experienced goldfish breeder receives two...Ch. 2 -
15. The accompanying pedigree shows the...Ch. 2 -
16. A geneticist crosses a pure-breeding strain...Ch. 2 - Suppose an F1 plant from Problem 16 is crossed to...Ch. 2 - 18. In pea plants, the appearance of flowers along...Ch. 2 - 19. If two six-sided dice are rolled, what is the...Ch. 2 - Experimental Insight 2.1 describes data, collected...Ch. 2 -
21. The accompanying pedigree shows the...Ch. 2 - 22. The seeds in bush bean pods are each the...Ch. 2 - List all the different gametes that are possible...Ch. 2 - Organisms with the genotypes AABbCcDd and AaBbCcDd...Ch. 2 - 25. Blue moon beans produce beans that are either...Ch. 2 - In the fruit fly Drosophila, a rudimentary wing...Ch. 2 - In pea plants, plant height, seed shape, and seed...Ch. 2 - A variety of pea plant called Blue Persian...Ch. 2 - 29. In tomato plants, the production of red fruit...Ch. 2 - A male and a female are each heterozygous for both...Ch. 2 - A woman expressing a dominant phenotype is...Ch. 2 - Two parents who are each known to be carriers of...Ch. 2 - 33. An organism having the genotype AaBbCcDdEe is...Ch. 2 - 34. A man and a woman are each heterozygous...Ch. 2 - For a single dice roll, there is a 16 chance that...Ch. 2 - You have four guinea pigs for a genetic study. One...Ch. 2 - 37. Galactosemia is an autosomal recessive...Ch. 2 - Sweet yellow tomatoes with a pear shape bring a...Ch. 2 - A cross between a spicy variety of Capsicum annum...Ch. 2 - Alkaptonuria is an infrequent autosomal recessive...Ch. 2 - 41. Humans vary in many ways from one another....Ch. 2 - 42. In chickens, the presence of feathers on the...Ch. 2 -
43. A pure-breeding fruit fly with the...Ch. 2 - 44. Situs inversus is a congenital condition in...Ch. 2 - 45. Domestic dogs evolved from ancestral grey...Ch. 2 - Alleles of the IGF-1 gene in dogs, encoding...Ch. 2 - 47. The accompanying pedigree shows a family in...Ch. 2 -
48. A pea plant that has the genotype RrGgwwdd is...Ch. 2 - Go to the OMIM website...Ch. 2 - Prob. 50PCh. 2 - Prob. 51PCh. 2 -
52. In humans, the ability to bend the thumb...
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- At the beginning of the film, you were introduced to Davaun and Skyy Cooper, who both have sickle cell disease. Which of the following must be true about their parents? Group of answer choices One parent has at least one copy of the sickle cell allele. Both parents have at least one copy of the sickle cell allele. Both parents have sickle cell disease. One parent has sickle cell disease.arrow_forwardBelow is a pedigree chart for a family that has a history of Alkaptonuria. Individuals infected with this condition can have darkened skin, brown urine, and can suffer from joint damage and other complications. Given this pedigree answer the following questions. Given the data in the pedigree chart is this genetic condition autosomal dominant or autosomal recessive? What are the genotypes for #1, #2, and #3? If either of the 4th generation "aa" females were to mate with a homozygous dominant male would any of their offspring illustrate the phenotype? Why or why not?arrow_forwardBased on the observed inheritance pattern and ratio of phenotypes, what are the genotypes of the affected children? Select an answer and submit it. For keyboard navigation, use the up/down arrow keys to select an answer. a) If c- = Cystic Fibrosis, the children are c-/c-. b) If c- = Cystic Fibrosis, the children are C/C. c) If c- = Cystic Fibrosis, the children are C/c-. d) If c- = Cystic Fibrosis, the children are C.arrow_forward
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- What is the genetic basis and phenotype for each of the following disorders (use proper genetic notation)? a. Edwards syndrome b. Patau syndrome c. Klinefelter syndrome d. Down syndromearrow_forwardPlease read the scenario below, and then answer the question (in bold) that follows. Tay-Sachs disease is a fatal autosomal recessive disorder in children (usually by age 5) that causes a progressive degeneration of the central nervous system. This disease affects 1 in 3,500 newborns of European Ashkenazi Jewish ancestry in the U.S. population. What is the number of carriers in the population? a. 1 person b. 60 persons c. 116 persons d. 3,383 persons e. 3,441 personsarrow_forwardNiemann Pick Type C disease is a recessive disorder that causes the accumulation of cholesterol and other lipids in lysosomes, ultimately affecting both the liver and the nervous system. Below are the genotypes and phenotypes of offspring of a family with a history of Niemann Pick. 7 NN ( all normal phenotype) 3 Nn (all normal phenotype) 4 nn (1 early onset dementia, 1 mid-life onset dementia, 2 late-onset dementia). From this information, Niemann-Pick disease is an example of: A) variable expressivity B) incomplete dominance C) incomplete penetrance D) variable expressivity and incomplete penetrance E) multiple allelesarrow_forward
- Using the given pedigree chart, suppose individuals III-1 and III-2 are expecting their sixth child. What is the chance (percent) that the sixth child will have the sickle cell trait? arrow_forwardHow we can know the rare inherited genetic disorders by the incidence ? Explain.arrow_forwardPlease find an Image/Graphic to represent sickle cell disease: Use at least two different images to help the audience understand the cause and/or inheritance pattern of the disorder you chose. Include a brief 1-2 sentence caption below each image that gives a description of the image and explains its relevance to your chosen disorder. The two images should NOT convey the same exact information. Ideas of images to use include: karyotypes, pedigrees, DNA sequences, etc. Please note: the images should be specific to your chosen disorder. The 2 required images must be related to cause and/or inheritance pattern. Images of an individual with the disorder will not count toward your 2 required images as they do not contribute to the audience's understanding of cause and/or inheritance pattern.arrow_forward
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