BIOCHEM-ACHIEVE(FIRST DAY DISCOUNTED)
9th Edition
ISBN: 2818000069358
Author: BERG
Publisher: MAC HIGHER
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 21, Problem 19P
Interpretation Introduction
Interpretation:
Reason for the glycogen depletion after strenuous exercise in a mice strain lacking phosphorylase kinase should be explained.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Lactic acid builds up in the athlete's thigh muscle after marathon training.
Compare and contrast the physiological functions and Vmax of glycogen phosphorylase in active skeletal muscle and liver.
The athlete faints after a rigorous workout owing to a low blood glucose level. A liver biopsy reveals that there is an excess of glycogen in the liver. Suggestions on whatever sort of enzyme is faulty in this circumstance should be accompanied by an explanation.
After the training of marathon, lactic acid is accumulated in the athlete's thigh muscle.
Compare the physiological functions and Vmax of glycogen phosphorylase in actively working skeletal muscle and that in liver
After vigorous exercise, the athlete faints due to low blood glucose level. A liver biopsy test shows excess amount of glycogen is present in the liver. Suggest with explanation, which type of enzyme is defective in this case.
It has been shown recently that the African naked
GLUT5-.O Fructose
(b)
mole-rat can withstand up to 18 min of complete anoxia (ab-
sence of O2) in the presence of high levels of CO2 without ap-
parent brain damage. The basis of its capacity to tolerate such
unusual conditions is that the brain, heart, and liver in the mole-
rat switch to fructose-driven glycolysis. In contrast to normal
mice, these tissues in the naked mole-rat have high levels of
GLUT5 specific for cellular uptake of fructose. The available
pathways for breakdown of fruct
ose for metabolic energy production are shown on the right.
KHK stands for ketohexosekinase, an enzyme that is markedly
upregulated in the mole-rat compared to normal mice. Conse-
quently mice must metabolize fructose largely via hexokinase
(HK). In the diagram ALDOB, ALDOA, etc. represent aldolase
isozymes.
KHK
HK
Fructose-6-P
PFK
Fructose-1-P
Fructose-1,6-BP
ALDOA
ALDOC
ALDOB
ALDOC
Glyceraldehyde
DHAP
GAЗP
Glyc-3-P
3-PGA
Lactate
Pyruvate
mouse…
Chapter 21 Solutions
BIOCHEM-ACHIEVE(FIRST DAY DISCOUNTED)
Ch. 21 - Prob. 1PCh. 21 - Prob. 2PCh. 21 - Prob. 3PCh. 21 - Prob. 4PCh. 21 - Prob. 5PCh. 21 - Prob. 6PCh. 21 - Prob. 7PCh. 21 - Prob. 8PCh. 21 - Prob. 9PCh. 21 - Prob. 10P
Ch. 21 - Prob. 11PCh. 21 - Prob. 12PCh. 21 - Prob. 13PCh. 21 - Prob. 14PCh. 21 - Prob. 15PCh. 21 - Prob. 16PCh. 21 - Prob. 17PCh. 21 - Prob. 18PCh. 21 - Prob. 19PCh. 21 - Prob. 20PCh. 21 - Prob. 21PCh. 21 - Prob. 22PCh. 21 - Prob. 23PCh. 21 - Prob. 24PCh. 21 - Prob. 25PCh. 21 - Prob. 26PCh. 21 - Prob. 27PCh. 21 - Prob. 28PCh. 21 - Prob. 29PCh. 21 - Prob. 30PCh. 21 - Prob. 31PCh. 21 - Prob. 32PCh. 21 - Prob. 33PCh. 21 - Prob. 34PCh. 21 - Prob. 35PCh. 21 - Prob. 36PCh. 21 - Prob. 37PCh. 21 - Prob. 38PCh. 21 - Prob. 39PCh. 21 - Prob. 40PCh. 21 - Prob. 41PCh. 21 - Prob. 42PCh. 21 - Prob. 43PCh. 21 - Prob. 44PCh. 21 - Prob. 45PCh. 21 - Prob. 46P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- .Intramitochondrial ATP concentrations are about 5 mM, and phosphate con- centration is about 10 mM. If ADP is five times more abundant than AMP, calculate the molar concentrations of ADP and AMP at an energy charge of 0.85. Calculate AG for ATP hydrolysis at 37 °C under these conditions. The energy charge is the concentration of ATP plus half the concentration of ADP divided by the total adenine nucleotide concentration: [ATP] + 1/2[ADP] [ATP] + [ADP] + [AMP]arrow_forwardIt has been shown recently that the African naked GLUT5-O Fructose mole-rat can withstand up to 18 min of complete anoxia (ab- sence of O2) in the presence of high levels of CO2 without ap- parent brain damage. The basis of its capacity to tolerate such unusual conditions is that the brain, heart, and liver in the mole- rat switch to fructose-driven glycolysis. In contrast to normal mice, these tissues in the naked mole-rat have high levels of GLUT5 specific for cellular uptake of fructose. The available pathways for breakdown of fruct ose for metabolic energy production are shown on the right. KHK stands for ketohexosekinase, an enzyme that is markedly upregulated in the mole-rat compared to normal mice. Conse- quently mice must metabolize fructose largely via hexokinase (HK). In the diagram ALDOB, ALDOA, etc. represent aldolase isozymes. KHK HK Fructose-6-P PFK Fructose-1-P Fructose-1,6-BP ALDOB ALDOC ALDOA ALDOC Glyceraldehyde DHAP GAЗP Glyc-3-P 3-PGA Lactate Pyruvate mouse naked…arrow_forwardCalculations based on the volume of a glucose residue and the branchingpattern of cellular glycogen indicate that a glycogen molecule could have up to 28 branching tiers before becoming impossibly dense. What are the advantages of such a molecule and why is it not found in vivo?arrow_forward
- Although animals cannot synthesize glucose from acetyl-CoA, if a rat is fed 14C-labeled acetate, some of the label appears in glycogen extracted from its muscles. Explain.arrow_forwardWhat would be the effect of the Glucagon initiated cascade on inhibition of ATP Synthase by IF1? Metabolic reprogramming in cancer cells correlates to an enhanced expression of IF1. What would be the effect on the TCA? Why might that lead to lactoacidosis?arrow_forwardAnimals cannot carry out a net conversion of even chain fatty acid carbon to glucose. However some of the carbons in odd-chain fatty acids can be gluconeogenic precursors to glucose. Explain.arrow_forward
- Intramitochondrial ATP concentrations are about 5 mM, and phosphate concentration is about 10 mM. If ADP is five times more abundant than AMP,calculate the molar concentrations of ADP and AMP at an energy charge of 0.85. Calculate ∆G for ATP hydrolysis at 37 °C under these conditions.The energy charge is the concentration of ATP plus half the concentration of ADP divided by the total adenine nucleotide concentration.arrow_forwardFructose 2,6-bisphosphate is a potent stimulator of phosphofructokinase. Explain how fructose 2,6-bisphosphate might function in the concerted model for allosteric enzymes.arrow_forwardType VI glycogen storage disease (Hers disease) is a rare metabolic disorder caused by lack of phosphorylase kinase in the liver. In your own words describe how each of the following metabolic parameters/observations will be affected/unaffected in a person with Type VI GSD (a) Blood glucose levels, after fasting (e.g. before breakfast). (b) Blood glucose levels, immediately following a meal. (c) Storage of glycogen in the liver and muscles. (d) ATP concentration in the musclesarrow_forward
- The interconverison of DHAP and GAP greatly favors the formation of DHAP at equilibirum. Yet the conversion of DHAP by triose phosphate isomerase proceeds readily. Why?arrow_forwardResearchers investigating the role of fat metabolism in diabetes generated PPAR peroxisome proliferator-activated receptor gamma (PPARγ) knockout mice. When fed a high fat diet, these mice did not gain extra adipose tissue or display significant weight gain. Explain why this is the case.arrow_forwardIn class, I mentioned that fructose is metabolized differently in the liver compared to glucose. Refer to the figure shown below to calculate the number ofATPs you would expect from the metabolism of fructose in the liver. Show your work! Fructokinase Fructose Fructose-1-P АТР ADP Aldolase B Dihydroxy- acetone phosphate Glyceraldehyde АТР Triose kinase Triose phosphate isomerase ADP 4 - Glyceraldehyde-3-P Glycolysis Руruvate Acetyl-CoA Fatty acids and triglyceridesarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningBiology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY