BIOCHEMISTRY
BIOCHEMISTRY
9th Edition
ISBN: 2818440090622
Author: BERG
Publisher: MAC HIGHER
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Chapter 21, Problem 30P
Interpretation Introduction

Interpretation:

The complete oxidation of glucose 6-phosphate derived from free glucose yields30 molecules ATP, whereas the complete oxidation of glucose 6- phosphate derived from glycogen yields 31 molecules of ATP , this difference should be accounted.

Concept introduction:

Glycogen is a readily mobilized storage form of glucose. It is a very large, branched polymer of glucose residues that can be broken down to yield glucose molecules when energy is needed.

Enzyme phosphoglucomutase breakdown glycogen into glucose 6-phosphate. Catalyzed by the glycogen phosphorylase enzyme.

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The glucose/glucose-6-phosphate substrate cycle involves distinct reactions of glycolysis and gluconeogenesis that interconvert these two metabolites. Assume that under physiological conditions, [ATP] = [ADP]; [P;] = 1 mM. Consider the glycolytic reaction catalyzed by hexokinase: ATP + glucose ADP + glucose-6-phosphate AG = - 16.7 kJ/mol (a) Calculate the equilibrium constant (K) for this reaction at 298°K, and from that, calculate the maximum [glucose-6-phosphate]/ Iglucose] ratio that would exist under conditions where the reaction is still thermodynamically favorable. (b) Reversal of this interconversion in gluconeogenesis is catalyzed by glucose-6-phosphatase: glucose-6-phosphate + H20 = glucose + P AG" = -13.8 kJ/mol
The complete oxidation of glucose 6-phosphate derived from free glucose yields 30 molecules ATP, whereas the complete oxidation of glucose 6- phosphate derived from glycogen yields 31 molecules of ATP. Account for this difference.
In which of the following metabolic conversions is ATP “generated” during glycolysis?     Glucose —> Glucose-6-phosphate     1,3-Bisphosphoglycerate —> 3-Phosphoglycerate     Fructose-1,6-bisphosphate —> Dihydroxyacetone phosphate  +  Glyceraldehyde-3-phosphate     Glucose-6-phosphate —> Fructose-6-phosphate     2-Phosphoglycerate —> 3-Phosphoglycerate
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