Campbell Biology - Modified Mstingbiology
Campbell Biology - Modified Mstingbiology
10th Edition
ISBN: 9780321935311
Author: Reece
Publisher: PEARSON
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Chapter 21, Problem 5TYU

EVOLUTION CONNECTION Genes important in the embryonic development ol animals, such as homeobox-coniaining  genes, have been relatlvely well conserved during evolution; that is. they are more similar among different species than are many other genes. Explain why this is.

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Rates of evolution appear to vary in different lin-eages. For example, the rate of evolution in the rat lineageis significantly higher than in the human lineage. Theserate differences are apparent whether one looks at changesin nucleotide sequences that encode proteins and are sub-ject to selective pressure or at changes in noncoding nucle-otide sequences, which are not under obvious selectionpressure. Can you offer one or more possible explanationsfor the slower rate of evolutionary change in the humanlineage versus the rat lineage?
Just as anatomical homology can lead to vestigial structuressuch as human wisdom teeth and the wings of flightlessbirds, genetic homology can lead to vestigial DNA sequences.For example, most mammal species produce an enzyme,L-gulonolactone oxidase, that catalyzes the last step in the productionof vitamin C. The species that produce the enzyme areable to do so because they all inherited the gene that encodesit from a common ancestor. Humans, however, do not produceL-gulonolactone oxidase, so we can’t produce vitamin C ourselvesand must consume it in our diets. But even though wedon’t produce the enzyme, our cells do contain a stretch of DNAwith a sequence very similar to that of the enzyme-producinggene present in rats and most other mammals. The human version,though, does not encode the enzyme (or any protein). Weinherited this stretch of DNA from an ancestor that we share withother mammal species, but in us, the sequence has undergonea change that rendered it nonfunctional. (The…
Some of the mammalian Hox genes have been shown tobe more similar to one of the insect Hox genes than to theothers. Describe an experimental approach that wouldenable you to demonstrate this finding in a functionaltest in living flies.

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Campbell Biology - Modified Mstingbiology

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