(a)
Interpretation:
The given synthesis using amide as an intermediate is to be shown.
Concept introduction:
Amides are the acid derivatives that are less reactive and are synthesized by the reaction of an acid chloride with an amine. Amides are produced when esters react with
(b)
Interpretation:
The given synthesis using amide as an intermediate is to be shown.
Concept introduction:
Amides are the acid derivatives that are less reactive and are synthesized by the reaction of an acid chloride with an amine. Amides are produced when esters react with amines and ammonia. It is also produced by the partial hydrolysis of nitriles.
(c)
Interpretation:
The given synthesis using amide as an intermediate is to be shown.
Concept introduction:
Amides are the acid derivatives that are less reactive and are synthesized by the reaction of an acid chloride with an amine. Amides are produced when esters react with amines and ammonia. It is also produced by the partial hydrolysis of nitriles.
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Organic Chemistry Plus Masteringchemistry With Pearson Etext, Global Edition
- Which of these statements is NOT true about the reaction of amines with a cyclic anhydride like phthalic anhydride? a. Dimethylamine will give a cyclic imide product. b. Aniline will give a cyclic imide product. c. Triethylamine will give a cyclic imide product. d. The reaction undergoes a nucleophilic acyl substitution mechanism.arrow_forwardShow how you would use bromination followed by amination to synthesize the followingamino acids. (b) leucine (c) glutamic acidarrow_forwardShow how to synthesize the following amines from the indicated starting materials below. Each of the final products may require several sequential steps. Draw the structure for each of the steps and show the reagents required.  Starting material Final product b) Benzene m-bromoaniline c) ethylbenzene p-ethylaniline + o-ethylaniline d) benzene p-bromoaniline + o-bromoanilinearrow_forward
- Several additional amine syntheses are effectively limited to making primary amines. The reduction of azides and nitrocompounds and the Gabriel synthesis leave the carbon chain unchanged. Formation and reduction of a nitrile adds onecarbon atom. Show how these amine syntheses can be used for the following conversions.(a) allyl bromide S allylamine (b) ethylbenzene S p@ethylanilinearrow_forwardPredict the chemical name of compound B a. p-chlorobenzylamine b. 4-bromoaniline c. benzylamine d. p-chloronitrile e. p-chlorobenzaldehyde  2. What is the reaction name for the chemical transformation of A to B a. reductive amination b. catalytic reduction c. carbonyl dehydration d. Hofmann elimination e. Aldehyde rearrangementarrow_forwardShow how to prepare the following aromatic amines by aromatic nitration, followed by reduction. You may use benzene andtoluene as your aromatic starting materials. p-bromoanilinearrow_forward
- Several additional amine syntheses are effectively limited to making primary amines. The reduction of azides and nitrocompounds and the Gabriel synthesis leave the carbon chain unchanged. Formation and reduction of a nitrile adds onecarbon atom. Show how these amine syntheses can be used for the following conversions. (c) 1@bromo@3@phenylheptane S 3@phenylheptan@1@amine (d) 1@bromo@3@phenylheptane S 4@phenyloctan@1@aminearrow_forwardShow how you would use bromination followed by amination to synthesize the followingamino acids. leucinearrow_forwardShow how to prepare the following aromatic amines by aromatic nitration, followed by reduction. You may use benzene andtoluene as your aromatic starting materials. c) m-bromoanilinearrow_forward
- Show how you would use bromination followed by amination to synthesize the followingamino acids.(a) glycinearrow_forwardWhat must be the starting material to carry out the following reaction? a) butanamide b) 4-aminobutanol c) 1-amino-2-butanone d) propanamide e) butanenitrilearrow_forwardThe two most general amine syntheses are the reductive amination of carbonyl compounds and the reduction of amides.Show how these techniques can be used to accomplish the following syntheses.(a) benzoic acid S benzylamine (b) benzaldehyde S benzylamine(c) pyrrolidine S N@ethylpyrrolidine (d) cyclohexanone S N@cyclohexylpyrrolidine(e) HOOC¬(CH2)3 ¬COOH S pentane@1,5@diamine (cadaverine)arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning