(a)
To determine: The role of p-aminobenzoate in bacteria.
Introduction: The p-Aminobenzoate is important for the growth of bacteria in the culture medium and serves many important roles such as reversing the accumulation of AICAR in the culture medium.
(b)
To determine: The reason for the accumulation of AICAR in the culture medium
Introduction: AICAR is represented as 5-aminoimidazole-4-craboxamide ribonucleotide. It accumulates in the culture medium when sulfa drug called sulfanilamide is present in the medium. Sulfa drug also termed as sulfonamide is the anti-bacterial agent. Some sulfa drugs don’t contain the antibacterial property. In bacteria, they act as the competitive inhibitor of several enzymes. Hence, it inhibits the growth of their multiplication.
(c)
To determine: The mechanism by which excess p-aminobenzoate reverses the accumulation of AICAR
Introduction: p-Aminobenzoate performs various roles in bacteria. It works as a competitive inhibitor and is required for their growth and multiplication in culture medium.
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