Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 24, Problem 13P
Interpretation Introduction
Interpretation:
Why the involvement of FAD is important in the conversion of stearic acid to oleic acid should be discussed.
Concept Introduction:
In eukaryotes, addition of double bond to fatty acids does not occur until the fatty acid chain occupied its full length. But the dehydrogenation of stearoyl-CoA occurs in the middle of the chain
Above reaction is catalyzed by stearoyl-CoA deaturase enzyme. This enzyme has a nonheme iron center. NADH and O2 is required to run this reaction. As well as, two other proteins cytochrome b5 reductase and cytochrome b5 are needed.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
The interconverison of DHAP and GAP greatly favors the formation of DHAP at equilibirum. Yet the conversion of DHAP by triose phosphate isomerase proceeds readily. Why?
Conjugation reactions in hepatocytes: glucuronidation reactions involving UDP-glucuronic acid.
The interconversion of DHAP and GAP greatly favors the formation of DHAP at equilibrium. Yet the conversion of DHAP by triose phosphate isomerase proceeds readily. Why
Chapter 24 Solutions
Biochemistry
Ch. 24 - Explaining the Stoichiometry of Fatty Acid...Ch. 24 - Tracing Carbon Atom Incorporation in Fatty Acids...Ch. 24 - Modeling the Regulation of AcetyI-CoA Carboxylase...Ch. 24 - Prob. 4PCh. 24 - Prob. 5PCh. 24 - Prob. 6PCh. 24 - Understanding the Stoichiometry of Cholesterol...Ch. 24 - Prob. 8PCh. 24 - Prob. 9PCh. 24 - Prob. 10P
Ch. 24 - Prob. 11PCh. 24 - Understanding the Mechanism of the...Ch. 24 - Prob. 13PCh. 24 - Understanding the Mechanism of the HMC-CoA...Ch. 24 - Prob. 15PCh. 24 - Prob. 16PCh. 24 - Prob. 17PCh. 24 - Prob. 18PCh. 24 - Prob. 19PCh. 24 - Prob. 20PCh. 24 - Prob. 21PCh. 24 - Prob. 22PCh. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - Prob. 25P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- IDENTIFICATION. One of the B-complex vitamins which is the precursor of Nicotinamide in the coenzyme NAD+. Carrier of the activated amino acids to the ribosomes for incorporation into the growing peptide chain. Molecule that attaches to myosin and actin during muscle contraction.arrow_forwardResearchers investigating the role of fat metabolism in diabetes generated PPAR peroxisome proliferator-activated receptor gamma (PPARγ) knockout mice. When fed a high fat diet, these mice did not gain extra adipose tissue or display significant weight gain. Explain why this is the case.arrow_forwardWhat biochemical reaction is catalyzed by γ-secretase? Why was it proposed that a chemical inhibitor of this activity might be a useful drug for treating Alzheimer’s disease? What possible side effects of such a drug would complicate this use?arrow_forward
- The regulation of Glutamine Synthetase (GS) in E.coli, a model for this highly conserved homodecamer in mammals, and is a striking example of cumulative feedback inhibition through allosteric regulation. Explain the cumulative feedback inhibition of GS..arrow_forwardTrue or false 1. Cytochrome p450 is considered to be the “universal oxygenase” 2. In alzheimer’s and Parkinson’s diseases, there is hyperphosphorylation of tau that leads to the intracellular accumulation of tau in the form of neurofibrillary tangles.arrow_forwardthe Effects of BPA on NFκB pathwayarrow_forward
- Inhibitors of acetylcholinesterase, such as edrophonium, are used to treat Alzheimer’s disease. The substrate for acetylcholinesterase is acetylcholine. Structures are attached. What kind of inhibitor is edrophonium? Explain. Can inhibition by edrophonium be overcome in vitro by increasing the substrate concentration? Explain. Does this inhibitor bind reversibly or irreversibly to the enzyme? Explain.arrow_forwardPredicted observation of precipitation of albumin with: - picric acid -tannic acid - 70% ethyl alcoholarrow_forwardOne treatment for hyperuricemia is administration of xanthine oxidase inhibitors like allopurinol. Discuss the mechanism and show an illustration how this drug able to alleviate symptoms of hyperuricemia.arrow_forward
- Mechanism of action and effects of Zuclopenthixol with diagrammatic representation.arrow_forward(No more than one page). Explain why quaternary structure is necessary for cooperativity and allosteric regulation. Use hemoglobin as an example. Include the various allosteric effectors that influence oxygen binding.arrow_forwardCrystal structures exist for three neurokinin-1 (NK1) ligand complexes with the following pdb codes (6hll, 6hlo, 6hlp) For each of the three crystal structures identify four amino acids in the NK1 binding site that contact the ligand indicating both the residue type in three letter code and the residue number. One of the chose amino acids should form a hydrogen binding interaction to the ligand, state which functional group the amino acid utilises in each casearrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Macromolecules | Classes and Functions; Author: 2 Minute Classroom;https://www.youtube.com/watch?v=V5hhrDFo8Vk;License: Standard youtube license