Concept explainers
(a)
Interpretation: To indicate whether the statement “pyruvate is converted to lactate in the skeletal muscle” relating to the Cori cycle is true or false.
Concept introduction: Glucose is converted to pyruvate by glycolysis
The Cori cycle is named after its discoverers, Gerty Radnitz Cori, and Carl Cori.
(b)
Interpretation: To indicate whether the statement “glucose from the liver travels to skeletal muscle as part of the cycle” relating to the Cori cycle is true or false.
Concept introduction: Glucose is converted to pyruvate by glycolysis metabolic pathway, pyruvate is further converted to lactate in the skeletal muscle cells by anaerobic reactions. The lactate is diffused into the bloodstream, by which it is transported to the liver. Lactate is reconverted to pyruvate. Gluconeogenesis metabolic pathway uses this pyruvate to synthesize glucose in the liver cells. Glucose is diffused into the bloodstream and is transported back to the active skeletal muscle cells. This cycle is known as the Cori cycle.
The Cori cycle is named after its discoverers, Gerty Radnitz Cori, and Carl Cori.
(c)
Interpretation: To indicate whether the statement “pyruvate is converted to lactate in the liver” relating to the Cori cycle is true or false.
Concept introduction: Glucose is converted to pyruvate by glycolysis metabolic pathway, pyruvate is further converted to lactate in the skeletal muscle cells by anaerobic reactions. The lactate is diffused into the bloodstream, by which it is transported to the liver. Lactate is reconverted to pyruvate. Gluconeogenesis metabolic pathway uses this pyruvate to synthesize glucose in the liver cells. Glucose is diffused into the bloodstream and is transported back to the active skeletal muscle cells. This cycle is known as the Cori cycle.
The Cori cycle is named after its discoverers, Gerty Radnitz Cori, and Carl Cori.
(d)
Interpretation: To indicate whether the statement “both lactate and pyruvate are present in skeletal muscle” relating to the Cori cycle is true or false.
Concept introduction: Glucose is converted to pyruvate by glycolysis metabolic pathway, pyruvate is further converted to lactate in the skeletal muscle cells by anaerobic reactions. The lactate is diffused into the bloodstream, by which it is transported to the liver. Lactate is reconverted to pyruvate. Gluconeogenesis metabolic pathway uses this pyruvate to synthesize glucose in the liver cells. Glucose is diffused into the bloodstream and is transported back to the active skeletal muscle cells. This cycle is known as the Cori cycle.
The Cori cycle is named after its discoverers, Gerty Radnitz Cori, and Carl Cori.
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