Concept explainers
(a)
Interpretation:
The intermediate that accumulates if aspartate is lacking in purine synthesis, is to be determined.
Concept introduction:
Purine is a heterocyclic ring, which is composed of a pyrimidine ring fused with an imidazole ring. Adenine and guanine found in DNA and RNA are purines. It is oxidized into uric acid by the action of xanthine oxidase. Further, it is also involved in the formation of certain alkaloids, such as caffeine, and theophylline.
(b)
Interpretation:
The intermediate that accumulates if tetrahydrofolate is lacking in purine synthesis, is to be determined.
Concept introduction:
Purine is a heterocyclic ring, which is composed of a pyrimidine ring fused with an imidazole ring. Adenine and guanine found in DNA and RNA are purines. It is oxidized into uric acid by the action of xanthine oxidase. Further, it is also involved in the formation of certain alkaloids, such as caffeine, and theophylline.
(c)
Interpretation:
The intermediate that accumulates if glycine is lacking in purine synthesis, is to be determined.
Concept introduction:
Purine is a heterocyclic ring, which is composed of a pyrimidine ring fused with an imidazole ring. Adenine and guanine found in DNA and RNA are purines. It is oxidized into uric acid by the action of xanthine oxidase. Further, it is also involved in the formation of certain alkaloids, such as caffeine, and theophylline.
(d)
Interpretation:
The intermediate that accumulates if glutamine is lacking in purine synthesis, is to be determined.
Concept introduction:
Purine is a heterocyclic ring, which is composed of a pyrimidine ring fused with an imidazole ring. Adenine and guanine found in DNA and RNA are purines. It is oxidized into uric acid by the action of xanthine oxidase. Further, it is also involved in the formation of certain alkaloids, such as caffeine, and theophylline.
Want to see the full answer?
Check out a sample textbook solutionChapter 25 Solutions
Biochemistry (Looseleaf)
- Help please. This question is specifically asking for the identification of the biomolecules that are attached to the sphingosine core, then we need to answer what bond causes those biomolecules to be connected to the sphingosine, what reaction created that bond (maybe addition or oxidation etc.), what were the starting materials and lastly what reagents or conditions are needed for the reaction to occur. Thank you!arrow_forwardI. Active site analysis. Below is a diagram of a putative active site for Monoamine oxidase. As we learned, the purpose of tertiary structure is to form a scaffold so you can orient just a few amino acids in the right orientation to promote binding and/or catalysis. The position where this occurs is the active site. The amino acid architecture of an active site is designed to bind substrates. Amino acid side chains are capable of hydrogen bonding, ionic and hydrophobic interactions. Fill in each amino acid that you think is suitable for interacting with the part of the substrate it is closest to. Assume the pH will be at 7.0 a.a.#1 a.a.#2 a.a.#6 HO Lond NH₂ НО a.a.#5 OH a.a.#3 a.a.#4arrow_forwardAnser in your own words. a. During pregnancy, do mother and child share the same blood? What if they have different blood types? b. If a patient takes a large dose of a drug that blocks calcium channels, what happens to the heart? c. The enzymes of the digestive system are classified as hydrolases. What does this mean? d. Explain in a scientific but simple manner the idiomatic expression “butterflies in my stomach”.arrow_forward
- Long explanations are not needed. Direct answers would suffice. a. Lactose, a disaccharide composed of galactose and glucose, is an example of ______. I. sugar phosphate II. reducing sugar III. non-reducing sugar b. The two most common amino sugars, B-D-glucosamine and B-D-galactosamine are formed from their respective carbohydrates by substitution of an amino group in place of the hydroxyl group on carbon _____. I. 3 II. 5 III. 2 IV. 4 V. 5arrow_forwardJust Arrange. The enzyme serine hydroxymethyltransferase (SHMT) requires pyridoxal phosphate (PLP) as a cofactor. Arrange the steps of the likely mechanism for SHMT‑catalyzed serine degradation (producing glycine and N5,N10‑methylenetetrahydrofolate)arrow_forwardCrohn’s disease. Omega-3 fatty acids have been tested asa means to prevent relapse of Crohn’s disease. Two large,randomized, placebo-controlled studies have shown nosuch benefit from omega-3 fatty acids. Suppose you areasked to design an experiment to further study this claim.Imagine that you have collected data on Crohn’s relapsesin subjects who have used these omega-3 fatty acids and similar subjects who have not used them and that you canmeasure incidences of relapse for these subjects. Statethe null and alternative hypotheses you would use in yourstudy.arrow_forward
- Long explanations are not needed. Direct answers would suffice. ***kind of in a hurry so having the answer asap would greatly be appreciated, thank you :)) a. Maltose contains 2 glucose units linked α1,4 and is a reducing sugar. i. True ii. False b. Which of the following polysaccharides contains glucose linked via β-1,4 glycosidic bonds? i. Amylopectin ii. Glycogen iii. Cellulose iv. Amylosearrow_forwardAmino AcidMetabolism. a. What are the SIXprecursors used in amino acid biosynthesis? b. What are the SEVEN metabolic intermediates that result from amino acid degradation? c. Circle the metabolites found in your answers to both a) & b) above. d) What is the difference between glucogenic and ketogenic amino acids? List the glucogenic amino acids, the ketogenic amino acids & the amino acids that are both glucogenic & ketogenic.arrow_forwardBIOCHEMISTRY DRAWING. pls accept question only if 100% confident please and thank you. Enalapril is inactive until acted upon by an esterase. Draw the structure of the resulting bioactive derivative. Hintarrow_forward
- Hi, help please. Discuss each method of regulating phosphofructokinase below as indicated by the circle. Discuss 1.) The type of regulation occurring, 2.) What compound or condition performs the regulation, 3.) How/why it influences the enzyme activity.arrow_forwardan inorganic ion. Such as metal ion, that improves the fit of an enzyme with its substrate is a(n)?arrow_forwardLong explanations are not needed. Direct answers would suffice. ***kind of in a hurry so having the answer asap would greatly be appreciated, thank you :)) a. Which of the following is FALSE about sucrose? i. It is a non-reducing sugar. ii. It is the transport sugar in plants. iii. It is a disaccharide. iv. Its monosaccharide units are linked via glycosidic bond α1→β1. v. It is composed of glucose and fructose. b. How many carbon atoms are found in the smallest molecules that can be classified as carbohydrates? i. 5 ii. 2 iii. 1 iv. 4 v. 3arrow_forward
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. FreemanLehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. FreemanFundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningFundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON