Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 26, Problem 16P
Interpretation Introduction

Interpretation:

The reason for histone deacetylase action to repress transcription should be explained.

Concept Introduction:

Acetylation and deacetylation of histones play essential role in regulating gene expression. Histone acetyltransferase (HAT) adds acetyl group to the conserved lysine residues whereas histone deacetylase (HDAC) has a reverse action i.e. removal of acetyl group. Both the enzymes play an important role in the regulation of gene expression and chromatin modeling.

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