5-Azacytidine is a reagent that suppresses DNA methylation through its conversion to 5-azadeoxycytidine triphosphate. A metabolic pathway leading from Aza-C to Aza-CTP is to be outlined. Concept Introduction: 5-Azacytidine is a chemical cytidine analog that can metabolize to 5-aza analog of dCTP and can incorporate itself into DNA. At Position 5 of 5-azacytidine, N is present instead of C, so 5-aza analog of dCTP cannot undergo methylation. Cancer cells treated with 5-azacytidine convert 5-mCpG dinucleotide to CpG in three rounds of replication. This treatment results in activation of genes repressed by DNA methylation. Pictorial Representation: Metabolic pathway leading from Aza-C to Aza-CTP is described as: (1) ATP dependent kinases (2) Ribonucleotide reductase (3) Nucleoside diphosphate kinase

Question

Want to see the full answer?

Answer 1

Question

Chapter 26, Problem 18P

Interpretation Introduction

Interpretation:

5-Azacytidine is a reagent that suppresses DNA methylation through its conversion to 5-azadeoxycytidine triphosphate. A metabolic pathway leading from Aza-C to Aza-CTP is to be outlined.

Concept Introduction:

5-Azacytidine is a chemical cytidine analog that can metabolize to 5-aza analog of dCTP and can incorporate itself into DNA. At Position 5 of 5-azacytidine, N is present instead of C, so 5-aza analog of dCTP cannot undergo methylation. Cancer cells treated with 5-azacytidine convert 5-mCpG dinucleotide to CpG in three rounds of replication. This treatment results in activation of genes repressed by DNA methylation.

Pictorial Representation:

Metabolic pathway leading from Aza-C to Aza-CTP is described as:

(1) ATP dependent kinases (2) Ribonucleotide reductase (3) Nucleoside diphosphate kinase

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 2

Question

Chapter 26, Problem 18P

Interpretation Introduction

Interpretation:

5-Azacytidine is a reagent that suppresses DNA methylation through its conversion to 5-azadeoxycytidine triphosphate. A metabolic pathway leading from Aza-C to Aza-CTP is to be outlined.

Concept Introduction:

5-Azacytidine is a chemical cytidine analog that can metabolize to 5-aza analog of dCTP and can incorporate itself into DNA. At Position 5 of 5-azacytidine, N is present instead of C, so 5-aza analog of dCTP cannot undergo methylation. Cancer cells treated with 5-azacytidine convert 5-mCpG dinucleotide to CpG in three rounds of replication. This treatment results in activation of genes repressed by DNA methylation.

Pictorial Representation:

Metabolic pathway leading from Aza-C to Aza-CTP is described as:

(1) ATP dependent kinases (2) Ribonucleotide reductase (3) Nucleoside diphosphate kinase

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Chapter 26, Problem 18P

Interpretation Introduction

Interpretation:

5-Azacytidine is a reagent that suppresses DNA methylation through its conversion to 5-azadeoxycytidine triphosphate. A metabolic pathway leading from Aza-C to Aza-CTP is to be outlined.

Concept Introduction:

5-Azacytidine is a chemical cytidine analog that can metabolize to 5-aza analog of dCTP and can incorporate itself into DNA. At Position 5 of 5-azacytidine, N is present instead of C, so 5-aza analog of dCTP cannot undergo methylation. Cancer cells treated with 5-azacytidine convert 5-mCpG dinucleotide to CpG in three rounds of replication. This treatment results in activation of genes repressed by DNA methylation.

Pictorial Representation:

Metabolic pathway leading from Aza-C to Aza-CTP is described as:

(1) ATP dependent kinases (2) Ribonucleotide reductase (3) Nucleoside diphosphate kinase

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Chapter 26, Problem 18P

Interpretation Introduction

Interpretation:

5-Azacytidine is a reagent that suppresses DNA methylation through its conversion to 5-azadeoxycytidine triphosphate. A metabolic pathway leading from Aza-C to Aza-CTP is to be outlined.

Concept Introduction:

5-Azacytidine is a chemical cytidine analog that can metabolize to 5-aza analog of dCTP and can incorporate itself into DNA. At Position 5 of 5-azacytidine, N is present instead of C, so 5-aza analog of dCTP cannot undergo methylation. Cancer cells treated with 5-azacytidine convert 5-mCpG dinucleotide to CpG in three rounds of replication. This treatment results in activation of genes repressed by DNA methylation.

Pictorial Representation:

Metabolic pathway leading from Aza-C to Aza-CTP is described as:

(1) ATP dependent kinases (2) Ribonucleotide reductase (3) Nucleoside diphosphate kinase

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 5

Chapter 26, Problem 18P

Interpretation Introduction

Interpretation:

5-Azacytidine is a reagent that suppresses DNA methylation through its conversion to 5-azadeoxycytidine triphosphate. A metabolic pathway leading from Aza-C to Aza-CTP is to be outlined.

Concept Introduction:

5-Azacytidine is a chemical cytidine analog that can metabolize to 5-aza analog of dCTP and can incorporate itself into DNA. At Position 5 of 5-azacytidine, N is present instead of C, so 5-aza analog of dCTP cannot undergo methylation. Cancer cells treated with 5-azacytidine convert 5-mCpG dinucleotide to CpG in three rounds of replication. This treatment results in activation of genes repressed by DNA methylation.

Pictorial Representation:

Metabolic pathway leading from Aza-C to Aza-CTP is described as:

(1) ATP dependent kinases (2) Ribonucleotide reductase (3) Nucleoside diphosphate kinase

Answer 6

Chapter 26, Problem 18P

Interpretation Introduction

Interpretation:

5-Azacytidine is a reagent that suppresses DNA methylation through its conversion to 5-azadeoxycytidine triphosphate. A metabolic pathway leading from Aza-C to Aza-CTP is to be outlined.

Concept Introduction:

5-Azacytidine is a chemical cytidine analog that can metabolize to 5-aza analog of dCTP and can incorporate itself into DNA. At Position 5 of 5-azacytidine, N is present instead of C, so 5-aza analog of dCTP cannot undergo methylation. Cancer cells treated with 5-azacytidine convert 5-mCpG dinucleotide to CpG in three rounds of replication. This treatment results in activation of genes repressed by DNA methylation.

Pictorial Representation:

Metabolic pathway leading from Aza-C to Aza-CTP is described as:

(1) ATP dependent kinases (2) Ribonucleotide reductase (3) Nucleoside diphosphate kinase

Answer 7

Chapter 26, Problem 18P

Interpretation Introduction

Interpretation:

5-Azacytidine is a reagent that suppresses DNA methylation through its conversion to 5-azadeoxycytidine triphosphate. A metabolic pathway leading from Aza-C to Aza-CTP is to be outlined.

Concept Introduction:

5-Azacytidine is a chemical cytidine analog that can metabolize to 5-aza analog of dCTP and can incorporate itself into DNA. At Position 5 of 5-azacytidine, N is present instead of C, so 5-aza analog of dCTP cannot undergo methylation. Cancer cells treated with 5-azacytidine convert 5-mCpG dinucleotide to CpG in three rounds of replication. This treatment results in activation of genes repressed by DNA methylation.

Pictorial Representation:

Metabolic pathway leading from Aza-C to Aza-CTP is described as:

(1) ATP dependent kinases (2) Ribonucleotide reductase (3) Nucleoside diphosphate kinase

Answer 8

Expert Solution & Answer

Answer 9

Expert Solution & Answer

Answer 10

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 11

Ch. 26 - Prob. 1P Ch. 26 - Is attenuation likely to be involved in eukaryotic...Ch. 26 - Prob. 3P Ch. 26 - Prob. 4P Ch. 26 - Prob. 5P Ch. 26 - Prob. 6P Ch. 26 - Prob. 7P Ch. 26 - Prob. 8P Ch. 26 - Prob. 9P Ch. 26 - Prob. 10P

Concept explainers

Videos

Want to see the full answer?

Chapter 26 Solutions