Concept explainers
(a)
To draw: The structure of the modified base formed after N6 methylation of adenosine residues in mRNA.
Introduction: In eukaryotes, transcription occurs in the nucleus and pre-mRNA is synthesized. This pre-mRNA is further modified before translation in the cytoplasm. N6 methylation of adenosine residues is the common post-transcriptional modification in pre-mRNA sequences of the eukaryotes.
(b)
To determine: Whether the modification is expected to alter the RNA’s ability to form the stem-loop structures.
Introduction: In eukaryotes, transcription occurs in the nucleus and pre-mRNA is synthesized. This pre-mRNA is further modified before translation in the cytoplasm. N6 methylation of adenosine residues is the common post-transcriptional modification in pre-mRNA sequences of the eukaryotes.
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