Concept explainers
(a)
Interpretation:
The reason for alterations of given ratios by alcohol consumption should be determined.
Concept introduction:
Alcohol consumption leads to physiological dysfunctions, which are caused due to binding of alcohol on the specific sites of neuronal proteins. Such bindings occur in water-filled pockets in the brain, resulting in alterations of protein’s conformations and functions.
(b)
Interpretation:
The cause of hypoglycemia and acidosis should be determined in hungry individual.
Concept introduction:
Alcohol consumption leads to physiological dysfunctions, which are caused due to binding of alcohol on the specific sites of neuronal proteins. Such bindings occur in water-filled pockets in the brain, resulting in alterations of protein’s conformations and functions.
(c)
Interpretation:
The reason for no hypoglycemia in fell fed person should be determined.
Concept introduction:
Alcohol consumption leads to physiological dysfunctions, which are caused due to binding of alcohol on the specific sites of neuronal proteins. Such bindings occur in water-filled pockets in the brain, resulting in alterations of protein’s conformations and functions.
Want to see the full answer?
Check out a sample textbook solutionChapter 27 Solutions
BIOCHEM-ACHIEVE(FIRST DAY DISCOUNTED)
- Can someone help with this question?arrow_forwardPlease select appropriate word in each bracket Glycogen provides short term energy storage primarily in liver and muscle. Defects in the enzymes that are required for either glycogen synthesis or breakdown therefore affect levels of [ Select ] ["glucose", "glycogen"] in the bloodstream and the amount of glycogen in the liver. This is exemplified by defects in [ Select ] ["glucose-6-phosphatase", "glycogen synthase"] , which is a deficit in breakdown and delivery, whereas mutations compromising [ Select ] ["glycogen synthase", "glycogen debranching enzyme"] result in a defect in synthesis, but defects in either enzyme produce [ Select ] ["hypoglycemia", "hypothermia"].arrow_forwardWhat is the metabolic significance of the following observations? (1) Only the liver form of pyruvate kinase is inhibited by alanine, and (2) only gluco- neogenic tissues contain appreciable levels of glucose-6-phosphatase.arrow_forward
- . Glucagon secretion causes inhibition of intracellular acetyl-CoA car- boxylase activity by several mechanisms. Name all you can think of.arrow_forwardWhich of the following glycolytic enzymes catalyzes the conversion of fructose-1,6-bisphosphate into the two product molecules dihydroxyacetone phosphate, and glyceraldehyde-3-phosphate? phosphoglycerate kinase pyruvate kinase malate dehydrogenase aldolase phosphofructokinasearrow_forwardDescribe the gluconeogenesis. What are the substrates for gluconeogenesis? (yellow boxes) and write the names of the enzymes belong to the gluconeogenic pathway. Glucose 4 se-6-phosphate usphoglucose isomerase Fructose-6-phosphate Fructose-1,6-bisphosphate HAidolase Triose phosphate Dihydroxyacetone phosphate isomerase Glyceraldehyde 3-phosphate P.. NAD CH,OH Glyceraldehyde 3-phosphate dehydrogenase 1,3-Bisphosphoglycerate CH,OPO,- NADH ADP Phosphoglycerate kinase ATP 3-Phosphoglycerate Phosphoglycerate || mutase 2-Phosphoglycerate 2 X Enolase Phosphoenolpyruvate GDP, CO, GIP Oxaloacetate ADP + P, 1 ATP, HCOS Pyruvatearrow_forward
- Write a one-sentence explanation for each of the following statements. (a) In liver, glucagon stimulates glycogen breakdown via cyclic AMP. Although one might expect glucagon also to stimulate catabolism of the glucose formed, glucagon inhibits glycolysis and stimulates glu- coneogenesis in liver. (b) An individual with a glucose-6-phosphatase deficiency suffers from chronic hypoglycemia. (c) The action of phosphorylase kinase simultaneously activates glycogen breakdown and inhibits glycogen synthesis. (d) The presence in liver of glucose-6-phosphatase is essential to the function of the liver in synthesizing glucose for use by other tissues.arrow_forwardMy teacher did not go over this really well in class so i'm looking for extra help.arrow_forwardWhich of the following statements is true for the shown reactions? Deficiency of oxaloacetate stimulates the formation of X and y Insulin signaling stimulates the formation of X and Y Both A and B Neither A nor Barrow_forward
- 4+ Predict the effects of the following on glycogen metabolism and briefly explain your choice. Change Occurring Effect on glycogen levels body wide (including any tissue specific effects) Debranching enzyme has 50% of normal activity KM of G-6-Pase is 10 times higher than normal Hexokinase has 5% of normal Vmax Effect on blood glucose levelsarrow_forwardWith respect to glycogen, what is the likely fate of excess glucose 6-phosphate in muscle?arrow_forwardWhy is oxaloacetate depletion from the TCA cycle important for the initiation of ketogenesis? What causes this oxaloacetate depletion? What tissue type in our body is this oxaloacetate depletion found and why is it not found in other tissues?arrow_forward
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning