Biochemistry
8th Edition
ISBN: 9781464126109
Author: Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr., Lubert Stryer
Publisher: W. H. Freeman
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Question
Chapter 29, Problem 19P
Interpretation Introduction
Interpretation:
The mutation that results in the synthesis of the modified mRNA of a thalassemic patient should be determined.
Concept introduction:
RNA synthesis (transcription) is the synthesis of an RNA molecule from the nucleotide’s adenine, cytosine, guanine, or uracil. The
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Be sure to answer all parts.
Write a possible mRNA sequence that codes for each peptide.
a. His-Cys-Tyr-Val-Ser
5¹-
b. Phe-Val-Thr-Tyr-Glu
5'-
5'-
c. Trp-Phe-Asn-Gln
-3'
U
-3'
с
Table 26.2 The Genetic Code-Triplets in Messenger RNA
First Base
(5' end)
-3'
U
UUU
UUC
UUA
UUG
CUU
CUC
CUA
CUG
AUL
Phe
Phe
Leu
Leu
Leu
Leu
Leu
Leu
la
C
UCU
UCC
UCA
UCG
CCU
CCC
CCA
CCG
Second Base
A
UAU
UAC
UAA
UAG
CAU
CAC
CAA
CAG
Ser
Ser
Ser
Ser
Pro
Pro
Pro
Pro
Tyr
55
Tyr
Stop
Stop
His
His
Gin
Gin
G
UGU
UGC
UGA
UGG
CGU
CGC
CGA
CGG
Cys
Cys
Stop
Trp
Arg
Arg
Arg
Arg
Third Base
(3¹ ond)
DUAC DU AG
с
А
А
AAAGAGAAAAGAAUA
to AAAGAGAAAUGAAUA.
Suppose the codon sequence
has a single base pair mutation
If the old protein sequence was Lys-Glu-Lys-Arg-Ile, what will be the new sequence encoded by the mutant gene?
(Use the 3-letter amino acid abbreviations with hyphens and no spaces in between, i.e. Ser-Asn-Tyr-Leu-Pro.)
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Retry Entire Group No more group attempts remain
Leaderless. The MRNA for the A repressor begins with 5'-AUG-3',
5'-AUG-3', which encodes the methionine residue that begins the
protein. What is unusual about this beginning? Would it cause the
MRNA to translate efficiently or not?
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