Chapter 29, Problem 7P

Interpretation Introduction

Interpretation:

The effect of a mutation that avoids the σ subunit from separating from the RNA polymerase core should be determined.

Concept introduction:

Non-competitive inhibition can be defined as a type of enzyme inhibition. In this inhibition, usually, the inhibitor diminishes the enzyme activity. The inhibitor gets fixed like the normal substrate does to the enzyme. It occurs even if it has been previously bound or not to the substrate. Unlike competitive inhibition, non-competitive inhibition cannot be overcome with the additional substrate.