Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 3, Problem 25P
Lesch–Nyhan syndrome (OMIM 300322) is a rare X-linked recessive disorder that produces severe mental retardation, spastic cerebral palsy, and self-mutilation.
a. What is the probability that the first son of a woman whose brother has Lesch–Nyhan syndrome will be affected?
b. If the first son of the woman described in (a) is affected, what is the probability that her second son is affected?
c. What is the probability that the first son of a man whose brother has Lesch–Nyhan syndrome will be affected?
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Chapter 3 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 3 - Examine the following diagrams of cells from an...Ch. 3 - Our closest primate relative, the chimpanzee, has...Ch. 3 -
3. In a test of his chromosome theory of...Ch. 3 - Cohesion between sister chromatids, as well as...Ch. 3 - 5. The diploid number of the hypothetical animal...Ch. 3 - 6. An organism has alleles R1 and R2 on one pair...Ch. 3 - Explain how the behavior of homologous chromosomes...Ch. 3 - 8. Suppose crossover occurs between the homologous...Ch. 3 -
9. Alleles A and a are on one pair of autosomes,...Ch. 3 - Prob. 10P
Ch. 3 - Describe the role of the following structures or...Ch. 3 - A womans father has ornithine transcarbamylase...Ch. 3 - In humans, hemophilia A (OMIM 306700) is an...Ch. 3 -
14. A wild-type male and a wild-type female...Ch. 3 - 15. A woman with severe discoloration of her tooth...Ch. 3 - 16. In a large metropolitan hospital, cells from...Ch. 3 - In cats, tortoiseshell coat color appears in...Ch. 3 - 18. The gene causing Coffin–Lowry syndrome (OMIM...Ch. 3 - 19. Four eye-color mutants in Drosophila—apricot,...Ch. 3 - 20. For each pedigree shown,
a. Identify which...Ch. 3 - 21. Use the blank pedigrees provided to depict...Ch. 3 - 22. Figure 3.22 (page 89) illustrates reciprocal...Ch. 3 - 23. In fruit flies, yellow body (y) is recessive...Ch. 3 - 24. In a species of fish, a black spot on the...Ch. 3 - LeschNyhan syndrome (OMIM 300322) is a rare...Ch. 3 - 26. In humans, SRY is located near a...Ch. 3 - 27. In an 1889 book titled Natural Inheritance...Ch. 3 - 28. In Drosophila, the X-linked echinus eye...Ch. 3 - 29. A wild-type Drosophila male and female are...Ch. 3 - 30. Drosophila has a diploid chromosome number of...Ch. 3 - The cell cycle operates in the same way in all...Ch. 3 - 33. Form a small discussion group and decide on...Ch. 3 - 34. Duchenne muscular dystrophy (DMD; OMIM 310200)...Ch. 3 - Prob. 35P
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- Given the karyotype shown at right, is this a male or a female? Normal or abnormal? What would the phenotype of this individual be?arrow_forwardHuman sex chromosomes are XX for females and XY for males. a. With respect to an X-linked gene, how many different types of gametes can a male produce? b. If a female is homozygous for an X-linked allele, how many different types of gametes can she produce with respect to this allele? c. If a female is heterozygous for an X-linked allele, how many different types of gametes can she produce with respect to this allele?arrow_forwardJan and Michael are both carriers for the cystic fibrosis allele. If Jan and Michael have three children with the disease and then Jan becomes pregant with fratnernal twins, what is the probability that both twins will also have the disease?arrow_forward
- I will be adding two questions here because I asked two of the same questions twice by accident earlier. A man and a woman do not have hemophilioa, but the womans father did. (Hemophilia is X-linked recessive). a) What is the probability that they will have a child with hemophilia? b) Is it possible for any of their daughters to be affected? Explain. A cross between a horse homozygous for red hair and a horse homozygous for white hair results in offspring with the coat colour called roan. When you look at the fur of the roan offspring you see both red and white hairs. What type of inheritance best explains this? a) blending inheritance b)codominance c)incomplete codominance d)multiple allelesarrow_forwardDuchenne muscular dystrophy is a sex-linked recessive disorder characterized by a progressive loss of muscle tissue. Neither Carla nor Rudy has Duchenne muscular dystrophy, but their first son does have it. What can you say about Rudy's or Carla's genotype in relation with the disorder? If the couple has a second child, what is the probability that he or she will also have the disease? Show your answers with a Punnet square.arrow_forwardColor-blindness is an X-linked, recessive trait. If a normal-sighted woman, whose father was color-blind, marries a color-blind man, what is the probability that they will have a son who is color-blind? (use the letter “B”)arrow_forward
- A karyotype shows that a child has Klinefelter syndrome (47,XXY). If the child is also colorblind (due to a recessive X-linked allele), despite his parents having normal color vision, in which parent and stage of meiosis did nondisjunction occur? And explain why .arrow_forwardDuchenne muscular dystrophy, which is inherited in an X-linked recessive pattern, nearly always occurs in males. Explain why.arrow_forwardwhat is the probability that a couple (both heterozygous for the same recessive mutation) will have two children with the disease if the couple plans to have four children in total?arrow_forward
- Ann's family has a history of cystic fibrosis, a recessive genetic disease. In the pedigree, family members who are afflicted with the disease are shown in red. Members who are unafflicted may or may not be carriers. Which of the given family members can be identified definitively as unafflicted carriers of cystic fibrosis?arrow_forwardDuchenne Muscular Dystrophy (DMD) is an X-linked recessive trait. Fill in a Punnett square for a man with DMD and a woman who carries DMD. Then use your Punnett square to answer the following questions: A) What is the probability that one of their daughters will have DMD? ___% B) What is the probability that one of their daughters is a carrier of DMD? ______ % C) What is the probability that one of their sons will have DMD? ______ % D) What is the probability that one of their sons is a carrier of DMD? ______ % E) On which chromosome is the gene for DMD located? _____arrow_forwardIs this pedigree dominant or recessive. Which best defines this pedigree Autosomal or sex-linked?arrow_forward
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