The data set in Table 3.12 is based on 214 children with acute otitis media (otitis media with effusion, or OME) who participated in a randomized clinical trial [13], Each child had OME at the beginning of the study in either one (unilateral cases) or both (bilateral cases) ears and was randomly assigned to receive a 14-day course of one of two antibiotics, either cefaclor (CEF) or amoxicillin (AMO). The data here concern the 203 children whose middle-ear status was determined during a 14-day follow-up visit. The data in Table 3.12 are presented in data set EAR.DAT (at www .cengagebrain.com).
TABLE 3.12 Format for EAR.DAT
Column Variable Format or code
1-3 ID
5 Clearance by 14 days 1 = yes/0 = no
7 Antibiotic 1 = CEF/2 = AMO
9 Age 1 = <2 yrs/2 = 2-5 yrs
3=6+ yrs
11 Ear 1 = 1st ear/2 = 2nd ear
Does there seem to be any difference in the effect of the antibiotics on clearance of otitis media? Express your results in terms of relative risk (RR). Consider separate analyses for unilateral and bilateral cases. Also consider an analysis combining the two types of cases.
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