BIOCHEMISTRY-ACHIEVE (1 TERM)
9th Edition
ISBN: 9781319402853
Author: BERG
Publisher: MAC HIGHER
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Chapter 30, Problem 6P
Interpretation Introduction
Interpretation:
The prediction of a mutation in the absence of other subunits of RNA polymerase that leads to the binding of σ to the -10 regions should be determined.
Concept introduction:
Non-competitive inhibition can be defined as a type of enzyme inhibition. In this inhibition, usually, the inhibitor diminishes the enzyme activity. The inhibitor gets fixed alike the normal substrate does to the enzyme. It occurs even if it has been previously bound or not to the substrate. Unlike competitive inhibition, non-competitive inhibition cannot be overcome with the additional substrate.
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An extra piece. In one type of mutation leading to a form of
thalassemia, the mutation of a single base (G to A) generates a new 3'
3' splice site (blue in the illustration below) akin to the normal one
(yellow) but farther upstream.
Normal 3' end
of intron
5' CCTATTGGTCTATTITCCACCCITAGGCTGCTG 3'
5' CCTATTAGTCTAIIIICCACCCTTAGGCTGCTG 3'
What is the amino acid sequence of the extra segment of protein
synthesized in a thalassemic patient having a mutation leading to
aberrant splicing? The reading frame after the splice site begins with
TCT.
Chapter 30 Solutions
BIOCHEMISTRY-ACHIEVE (1 TERM)
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