The reason for the lack of response to gram-negative bacteria due to a mutation in TLR4 should be determined. Concept introduction: The TLRs are the toll-like receptors thatplay an important role in the innate responses of the immune system. They are membrane-spanning, non-catalytic receptors. LPS is lipopolysaccharide that forms the outer membrane of the gram-negative bacteria.

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Chapter 35, Problem 11P

Interpretation Introduction

Interpretation:

The reason for the lack of response to gram-negative bacteria due to a mutation in TLR4 should be determined.

Concept introduction:

The TLRs are the toll-like receptors thatplay an important role in the innate responses of the immune system. They are membrane-spanning, non-catalytic receptors. LPS is lipopolysaccharide that forms the outer membrane of the gram-negative bacteria.

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