BIOCHEMISTRY
9th Edition
ISBN: 2818440090622
Author: BERG
Publisher: MAC HIGHER
expand_more
expand_more
format_list_bulleted
Question
Chapter 35, Problem 16P
Interpretation Introduction
Interpretation:
The peptide sequence presented by the class-I MHC molecules to HLA-A2 should be identified.
Concept introduction:
The HLA is the human immunocyte antigen. They encode the MHC (major histocompatibility Complex) in humans. The MHC plays a major role in antigen representation.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
sars-coV-2 spike protien
what is the isoelectric point of this peptide?
VGIYLQKTSDHRPEFALAMN
Sars-CoV-2 spike protein:
VGIYLQKTSDHRPEFALAMN
What is its isoelectric point of this peptide?
The peptlde bradykinln is a nonapeptlde. Give the name of the peptide (shown below)
by namlng the amlno aclds from the N-terminal to the C- terminal. Use the long name,
the 3-letter abbreviation and the 1-letter abbreviation. What is the pl of this peptide?
Name
Compositon
Fxnction
LOcalizatio
Bradykinl
Inflammatio Different
n and
H
N vasodilation Cells
HNH
n
Animal
H.
HNH
H
NH
он
HN
N
HO
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Please help. Did I label right ?arrow_forwardBONUS QUESTION! In neurons, the proteolytic enzyme y-secretase produces the Aß amyloid peptides shown below. The AB40 peptide is thought to play a protective role in the neuron. However, the AB42 peptide appears to be toxic since it is found in the amyloid plaques that cause Alzheimer's Disease (AD). AB40 and AB42 are identical, except that AB42 contains two extra amino acid residues (shown in red) at the C-terminal end. Based on your knowledge of amino acids and proteins, which of the following factors is most likely to explain the greater plaque-forming activity of AB42 compared to AB40? Sequence of Aß40: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV Sequence of AB42: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA O The greater length of AB42 makes it more likely to aggregate and form plaques. O AB42 has a lower pl than AB40, which makes it more likely to aggregate at physiological pH. O AB42 is more hydrophobic than AB40, which makes it harder to clear from the cell and thus more likely to…arrow_forwardI. A protein, X, was Isolated from a pathogenlc mlcroorganism. The proteln Is a vlrulence factor whose path0genlclty lies In a heptapeptide of unknown sequence. After trypsin cleavage of the heptapeptide from protein X, the peptlde's compOsition and sequence was determined. The fOllowing were the results of the sequenclng process: 1. When the peptide was treated with dinitrofluorobenzene (DNFB), DNP-asp and a mixture of amino acids were produced. 2. When the same Intact peptide was treated with streptococcal protease, a pentapeptide of composition asp, asN, cys, gly and ser and 2 amlno acids were released. 3. When the heptapeptlde was also treated with hydrOxylamine HCI, a tripeptide and a tetrapeptide were obtained. The C-terminal amino acid of the tripeptide was asN. 1) What is the sequence of the heptapeptide if it is composed of cys, asp, lys, asN, gly and ser only? 2) What is the pl of the heptapeptide?arrow_forward
- PROTEINS1. What will happen to free tyrosine after being subjected to xanthoproteic analysis (is it positive or negative, include color)2. What will happen to lysine after being subjected to millon's analysis (is it positive or negative, include color)arrow_forwardExplain the signifi cance of the observation that peptides such as fMet-Leu-Phe “activate” the phagocytotic (particle-engulfi ng) functions of mammalian leukocytes (white blood cells).arrow_forwardAntibody X binds to a polypeptide antigen with the following sequence: Leu-Ala-Phe-Val-Leu-Trp-Ala Based upon the sequence of the antigen, what amino acid in Antibody X would you expect to bind the antigen. ARG ILE ASP SER O LYS Provide a reason for why you chose the above amino acid based upon the biochemical properties of the antigen and the amino acid you chose.arrow_forward
- Draw the peptide provided in its most protonated form. (Upload your answer.) Arg - Cys - Asp - Valarrow_forward1 of 16 Data from an experiment is shown in the figure below. In the experiment, murine cells were treated with a specific a ligand that activates receptor R. In some cases, the cells were exposed to one of two drugs (X or Y) as well as the ligand or were left untreated (UT). After 30 minutes of treatment, the cells were lysed with a detergent-based buffer to release the soluble membrane, cyosolic and nuclear proteins. Samples from each cell extract were run (in duplicate) by SDS-PAGE (SDS-polyacrylamide gel electrophoresis) in order to separate the proteins by molecular mass (size). The separated proteins were then transferred to a nitrocellulose membrane which was then probed with different antibodies in a western blotting procedure to detect specific phosphorylated proteins or total proteins. If present in the cell extract, these proteins appear as a dark band in the relevant western blot image within the figure. Drug X Drug Y UT Ligand Ligand Ligand Western blotting antibodies…arrow_forwardHemoglobin variant Yakima contains His rather than Asp at the 99th description of hemoglobin Yakima. (Hint! Asp(99)B > His disrupts a H-bond that stabilizes the T state). position of each B chain (or the 1st position of G helix in B chain). Choose the best The p50 value of hemoglobin Yakima is lower than p50 of normal hemoglobin. O B. The p50 value of hemoglobin Yakima is higher than p50 of normal hemoglobin. The p50 value is not changed in hemoglobin Yakima. C. Hemoglobin Yakima will not bind O2 O D. O E. All of the abovearrow_forward
- . What physiological effect would you predict from a mutation that replaced with serine the cysteine in the constant part of the immunoglobulin light chain that is involved in disulfide-bond for- mation with the heavy chain? ,arrow_forwardconsider the given peptidesarrow_forwardAlpha polypeptide (ADH1A). Give a detailed description of its role in the disease. Describe the impact of the disease on society.Describe a way in which your gene can be manipulated to treat the disease. Assume you can make any changes to the protein product and describe specifically how it will affect its interaction with other molecules.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Infectious Diseases - How do we control them?; Author: Let's Learn Public Health;https://www.youtube.com/watch?v=2JWku3Kjpq0;License: Standard Youtube License