Investigating Biology Laboratory Manual (9th Edition)
9th Edition
ISBN: 9780134473468
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Judith Giles Morgan, M. Eloise Brown Carter
Publisher: PEARSON
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Chapter 43.1, Problem 2CC
MAKE CONNECTIONS Ø How do the molecules that activate the vertebrate TLR signal transduction pathway differ from the ligands in most other signaling pathways (see Concept 11.2)?
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DRAW IT Draw the following apoptotic pathway, whichoperates in human immune cells. A death signal isreceived when a molecule called Fas binds its cell-surfacereceptor. The binding of many Fas molecules to receptorscauses receptor clustering. The intracellular regions of thereceptors, when together, bind proteins called adaptorproteins. These in turn bind to inactive molecules ofcaspase-8, which become activated and then activatecaspase-3. Once activated, caspase-3 initiates apoptosis.
Create a diagram which illustrates the typical signalling mechanism of action of nuclear receptors
and possible routes of communication (autocrine etc.). Should show the specific molecules
involved, the mechanisms of signal transduction and indicate the different pathways thgt are
activated. It should include a specific example of a receptor, ligand and signalling pathway for
each general class. Include as wide a variety of ligands and modes of action as you can. for a
novel pathway.
Superfamily
Give the superfamily to which the receptor belongs
Accession
Give the Uniprot accession number
Name
Give the molecule name
Species
Give the species
Ligand
What is the ligand, or class of ligands which bind to this receptor?
Key
physiological
What are the physiological processes involved? Is this autocrine,
paracrine or endocrine or some combination of them? What is the
pathology of the receptor?
process
involved
Mechanism of What are the downstream actions of the receptor? Which molecules
does…
Put the steps of the process of signal transduction in the order they occur (hint - try to decide
which signaling pathway this is before working on the order):
1. A conformational change in the signal-receptor complex activates an enzyme.
2. Protein kinases are activated.
3. A signal molecule binds to a receptor.
4. Target proteins are phosphorylated.
5. Second messenger molecules are released.
O 1, 2, 3, 4, 5
O 3, 1, 2, 4, 5
O 1, 2, 5, 3, 4
O 3, 1, 5, 2, 4
I
Chapter 43 Solutions
Investigating Biology Laboratory Manual (9th Edition)
Ch. 43.1 - Pus is both a sign of infection and an indicator...Ch. 43.1 - MAKE CONNECTIONS How do the molecules that...Ch. 43.1 - Prob. 3CCCh. 43.2 - Prob. 1CCCh. 43.2 - Prob. 2CCCh. 43.2 - WHAT IF? If both copies of a light-chain gene and...Ch. 43.3 - Prob. 1CCCh. 43.3 - Treatment of antibodies with a particular protease...Ch. 43.3 - Prob. 3CCCh. 43.4 - Prob. 1CC
Ch. 43.4 - Prob. 2CCCh. 43.4 - WHAT IF? How would a macrophage deficiency likely...Ch. 43 - In what ways does innate immunity protect the...Ch. 43 - Why is the adaptive immune response to an initial...Ch. 43 - Is immunological memory after a natural infection...Ch. 43 - Prob. 43.4CRCh. 43 - Prob. 1TYUCh. 43 - An epitope associates with which part of an...Ch. 43 - Prob. 3TYUCh. 43 - Level 2: Application/Analysis 4. Which of the...Ch. 43 - Prob. 5TYUCh. 43 - Prob. 6TYUCh. 43 - Prob. 7TYUCh. 43 - Prob. 8TYUCh. 43 - MAKE CONNECTIONS Contrast clonal selection with...Ch. 43 - EVOLUTION CONNECTION Describe one invertebrate...Ch. 43 - Prob. 11TYUCh. 43 - Prob. 12TYUCh. 43 - SYNTHESIZE YOUR KNOWLEDGE This photo shows a child...
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