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Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892

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BuyFindarrow_forward

Biology: The Dynamic Science (Mind...

4th Edition
Peter J. Russell + 2 others
ISBN: 9781305389892
Textbook Problem

Nifedipine is an antihypertension medication that is also used to reduce the workload on the heart. The study below compares the effects of two different types of capsules used to administer the drug to patients (GITS—red line, and Cotracten X—blue line). Each graph shows changes with time following initial administra- tion of the capsules. Figure A compares the levels of nifedipine in the blood with each capsule type. The ability of the different cap- sules to reduce workload on the heart by altering blood pressure or heart rate is shown in Figures B and C, respectively.

Chapter 44, Problem 3ITD, Nifedipine is an antihypertension medication that is also used to reduce the workload on the heart. , example  1

Chapter 44, Problem 3ITD, Nifedipine is an antihypertension medication that is also used to reduce the workload on the heart. , example  2

Chapter 44, Problem 3ITD, Nifedipine is an antihypertension medication that is also used to reduce the workload on the heart. , example  3

Which type of capsule would you expect to have fewer side effects?

Source: M. J. Brown and C. B. Toal. 2008. Formulation of long-acting nifedipine tablets influences the heart rate and sympathetic nervous system response in hypertensive patients. British Journal of Clinical Pharmacology 65:646–652.

Summary Introduction

To review:

On the basis of the data given in the problem, we are required to estimate the side effects of given capsules, Contracten X and GITS, in blood plasma of a patient.

Introduction:

Hypertension is a case in which heart rate starts increasing day by day in a body of person. For the treatment of hypertension, a drug Nifedipine is used to treat hypertension, and it also includes chest pain. This drug is taken orally by the patient 3 times a day with food or without food, prescribed by the doctor. After taking this drug, it shows some side effects on the body like nausea, vomiting, muscle cramps, or constipation. The given data depicts the variation in heart beat rate after the treatment of drug in a patient with respect to time in hours.

Biology: The Dynamic Science (MindTap Course List), Chapter 44, Problem 3ITD

Explanation

The given drug GITS showed lower side effect over capsule Contracten X as per the given data. After studying the given data, it can be estimated that the capsule GITS slow the heart rate from 65 to 60 per minute in the duration of 3 hours after taking the drug by the patient. It can be also noted that in less concentration, which goes up to a maximum of 10 ng/mL this drug showed effective results with minimum side effects...

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