Concept explainers
(a)
Interpretation:
The configuration of the given compound has to be predicted.
Concept introduction:
Enantiomers are named by following Cahn-Ingold-Prelog system, in which R or S letter is used to differentiate between enantiomers.
According to Cahn-Ingold-Prelog system,
The group attached to asymmetric center should be ranked based on the
Check the direction of arrow drawn in the direction of decreasing priority. If the arrow points clockwise direction, then the compound has R configuration. If the arrow points counterclockwise direction, then the compound has S configuration. If the group with lowest priority is not bonded by a hatched wedge, then interchange this group (lowest priority) by group bonded to hatched wedge and draw the arrow in priority order but the configuration is assigned as just reverse.
(b)
Interpretation:
The configuration of the given compound has to be predicted.
Concept introduction:
Enantiomers are named by following Cahn-Ingold-Prelog system, in which R or S letter is used to differentiate between enantiomers.
According to Cahn-Ingold-Prelog system,
The group attached to asymmetric center should be ranked based on the atomic number of atom which directly connected to asymmetric center. The higher the atomic number of atom, higher the priority. If there is tie, then consider the next atoms attached to the connected atom and so on.
Check the direction of arrow drawn in the direction of decreasing priority. If the arrow points clockwise direction, then the compound has R configuration. If the arrow points counterclockwise direction, then the compound has S configuration. If the group with lowest priority is not bonded by a hatched wedge, then interchange this group (lowest priority) by group bonded to hatched wedge and draw the arrow in priority order but the configuration is assigned as just reverse.
(c)
Interpretation:
The configuration of the given compound has to be predicted.
Concept introduction:
Enantiomers are named by following Cahn-Ingold-Prelog system, in which R or S letter is used to differentiate between enantiomers.
According to Cahn-Ingold-Prelog system,
The group attached to asymmetric center should be ranked based on the atomic number of atom which directly connected to asymmetric center. The higher the atomic number of atom, higher the priority. If there is tie, then consider the next atoms attached to the connected atom and so on.
Check the direction of arrow drawn in the direction of decreasing priority. If the arrow points clockwise direction, then the compound has R configuration. If the arrow points counterclockwise direction, then the compound has S configuration. If the group with lowest priority is not bonded by a hatched wedge, then interchange this group (lowest priority) by group bonded to hatched wedge and draw the arrow in priority order but the configuration is assigned as just reverse.
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Chapter 4 Solutions
CHEM 262 ORG CHEM EBOOK DIGITAL DELIVERY
- Chloramphenicol is a broad-spectrum antibiotic that is particularly useful against typhoid fever. What is the configuration of each asymmetric carbon in chloramphenicol? HỌ H c-c-CH,OH NHCCHCI, NO2 chloramphenicolarrow_forwardCymbalta (shown below) is an antidepressant. How many asymmetric centers are present in this structure? SIN N.arrow_forwardDetermine the configuration of the following compounds (R or S) d. Br CI 'OHarrow_forward
- How many chiral centers are in the molecule shown below? O HNarrow_forwardWhich C-N bond in the following ions can undergo rotation? (draw a picture which represents bonding between C and N atoms to support your answer). CH3NH3+ CH2NH2+arrow_forwardWhich of the following contain(s) both sp-hybridized and sp3-hybridized carbon? OH3CCHCH₂ O H2CCCH2 OH3CCH₂CH3 O H3CCCH Larrow_forward
- 1. Which of the following compounds will not rotate the plane of polarization of plane- polarized light? OH OH | ОН ОН ОН ОН II ОН ОН ОН ||| ОН ОН ОН IVarrow_forwardConsider the following orbital diagram. What could be the structure of the compound represented by the orbital diagram? O NH2CH=CHCH3 O CH3CH2CONH2 O CH3CH=CHNH2 O CH3COOH O NH2CH=CHNH2 O CH3CH2CHO O All of the above.arrow_forwardIdentify e absolute configurations of all chiral centers in the following compounds. H CH3 H CI HO CH3 H, Bì Harrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning
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