Campbell Essential Biology (6th Edition) - standalone book
6th Edition
ISBN: 9780133917789
Author: Eric J. Simon, Jean L. Dickey, Jane B. Reece, Kelly A. Hogan
Publisher: PEARSON
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Chapter 5, Problem 11PS
HIV, the virus that causes AIDS, depends on an enzyme called reverse transcriptase to multiply. Reverse transcriptase reads a molecule of RNA and creates a molecule of DNA from it. A molecule of AZT, an anti-AIDS drug, has a shape very similar to (but a bit different than) that of the DNA base thymine. Propose a model for how AZT inhibits HIV.
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Tenofovir, an analog of adenosine monophosphate, is a nucleoside reverse transcriptase inhibitor used to treat HIV infection. Atazanavir, also used to treat HIV infection, is a protease inhibitor. Approximately 1 in 1,000 virus particles carries a mutation that confers resistance against any given anti-HIV drug. If there are 1010 virus particles circulating in a patient, roughly how many of them would be resistant to both tenofovir and atazanavir?
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104
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106
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107
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5 x 107
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1010
Proflavine was used to treat wounded soldiers in the Far East during the second world war. Which of the following statements is false regarding proflavine!
H₂N7
NH₂
Its target is located in the cell membrane.
Its planar shape is important to intercalation.
The primary amine groups are protonated and interact with phosphate groups of the DNA backbone.
When inserted into DNA, the tricyclic system can form van der Waals interactions with base pairs above and below it.
Which of the following would be a good chemotherapy approach: blocking formationof the ribonucleotide GTP or blocking formation of the deoxyribonucleotide dGTP?Why?
Please explain the chemical differences between each of the two nucleotides. Use the specific processes below to support your choice by explaining how either GTP or dGTPare related to these and how loss of the particular molecule would affect each process.
*PEP carboxykinase in gluconeogenesis*Succinyl-CoA synthetase in the TCA Cycle*Glucagon signal transduction
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Campbell Essential Biology (6th Edition) - standalone book
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