Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 50, Problem 15TYK
Summary Introduction

To review:

The experiment would convince that the human BCL2 protein is functional homologous to the worm CED-9 protein.

Introduction:

The Drosophila members of the Bcl-2 gene family whose function is important for programmed cell death. The Bcl-2 family of proteins has grown to include more than twenty members of death-suppressing and promoting molecules found in the genomes of worms, mammals, viruses, and flies. Likewise, cell death abnormality gene 9 (CED-9), is a gene found in Caenorhabditis elegans that inhibits or represses programmed cell death (apoptosis). It is also known as apoptosis regulator CED-9.

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What is an explanation for the similarities between genes in yeasts,nematodes, and mammals that control apoptosis?
Exposing C. elegans to an RNAi molecule homologous to a non-protein-coding RNA gene resulted in the worms’ inability to respond to touch. What predictions could you make about the function of that gene in development?
a. Explain how you could use worms transformedwith myo-2::GFP to find mutations that disrupt thestructure of the pharynx. How would the presenceof the transgene facilitate the mutant screen?b. Nematodes homozygous for loss-of-function mutations in a gene called pha-4 have no detectablepharyngeal structures. How could you use myo2::GFP to determine if pha-4 is a master regulatory gene that directs development of the pharynxin a manner similar to the way Pax-6/eyeless controls eye development?
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