Concept explainers
a)
Interpretation:
R and S configuration is to be assigned to the molecules by re-orienting the substituent.
Concept introduction:
Rule 1:
a) Higher
b) An atom node duplicated closer to the root ranks higher than one duplicated further.
Rule 2: Higher
Rule 3: Z precedes E and this precedes nonstereogenic (nst) double bonds.
Rule 4:
a) Chiral stereogenic units precede pseudoasymmetric stereogenic units and these precede nonstereogenic units (R = S > r = s > nst).
b) When two ligards have different descriptor pairs, the one with the first chosen like descriptor pairs has priority over the one with a corresponding unlike descriptor pairs.
c) r precedes s.
Rule 5: An atom or group with descriptor R has priority over its enantiomorph S.
b)
Interpretation:
R and S configuration is to be assigned to the molecules by re-orienting the substituent.
Concept introduction:
Rule 1:
a) Higher atomic number precedes lower.
b) An atom node duplicated closer to the root ranks higher than one duplicated further.
Rule 2: Higher atomic mass number precedes lower.
Rule 3: Z precedes E and this precedes nonstereogenic (nst) double bonds.
Rule 4:
a) Chiral stereogenic units precede pseudoasymmetric stereogenic units and these precede nonstereogenic units (R = S > r = s > nst).
b) When two ligards have different descriptor pairs, the one with the first chosen like descriptor pairs has priority over the one with a corresponding unlike descriptor pairs.
c) r precedes s.
Rule 5: An atom or group with descriptor R has priority over its enantiomorph S.
c)
Interpretation:
R and S configuration is to be assigned to the molecules by re-orienting the substituent.
Concept introduction:
Rule 1:
a) Higher atomic number precedes lower.
b) An atom node duplicated closer to the root ranks higher than one duplicated further.
Rule 2: Higher atomic mass number precedes lower.
Rule 3: Z precedes E and this precedes nonstereogenic (nst) double bonds.
Rule 4:
a) Chiral stereogenic units precede pseudoasymmetric stereogenic units and these precede nonstereogenic units (R = S > r = s > nst).
b) When two ligards have different descriptor pairs, the one with the first chosen like descriptor pairs has priority over the one with a corresponding unlike descriptor pairs.
c) r precedes s.
Rule 5: An atom or group with descriptor R has priority over its enantiomorph S.
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Chapter 5 Solutions
ORGANIC CHEM.(LL)-W/OWL V2 >CUSTOM<
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- Hypoglycin A, an aminoacid derivative found in unripened lychee, is a compound that is acutely toxic and can lead to death when ingested in large amounts by undernourished children. Draw all possible stereoisomers for hypoglycin A, and give the R,S designation for each stereocenter.arrow_forwardFor the molecules below, assign the stereocenter’s absolute configuration as R or Sarrow_forwardDetermine whether the circled hydrogens are enantiotopic, diastereotopic, heterotopic, or homotopic.arrow_forward
- For each compound given below, determine whether the two labeled hydrogens are homotopic, enantiotopic, or diastereotopic.arrow_forwardAssign R or S configurations to each stereogenic center of isoborneol and borneol. Give the relationship between these two stereoisomers.arrow_forwardFor each of the following compounds, give the correct R/S notation for all stereocentersarrow_forward
- How to ID and assign each stereocenter (using cahn, ingold) R, S system.arrow_forwardLabel the following stereocenters with asterisks.arrow_forwardIdentify the configuration of each chiral center of the following compounds: In the boxes below, first, input the number(s) corresponding to the chiral center(s) in numerical order as a comma separated list with no spaces (e.g "1,3,4"). Then input the configuration(s) of the chiral center(s) in the same order and format (e.g.." R,S,S"). Chiral center location(s): Configuration(s):arrow_forward
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