EBK BIOLOGY
EBK BIOLOGY
5th Edition
ISBN: 9780100667976
Author: Maier
Publisher: YUZU
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Chapter 6, Problem 2CTS
Summary Introduction

To analyze:

The person should be tested for the cell cycle mutations or not.

Knowing the presence of mutation of proto-oncogenes can be beneficial or not.

Introduction:

The proto-oncogenes are the genes, which regulate the cell cycles and the cell deaths. The main function of the proto-oncogenes is to maintain a specific number of cells. Some of the proto-oncogene regulates the cell cycle by the providing the signals to promote the cell division and some of the proto-oncogenes are involved in the programmed cell death of unwanted or damaged cell.

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Imagine that there are mutations in the CDK genes such that their gene products are nonfunctional. What effect would this mutation have on an immature unspecialized blood cell precursor found in the bone marrow? The cell would not be able to reproduce itself. The cell would complete the cell cycle using cyclins in the absence of CDKS. The cell would be able to replicate its DNA but not translate DNA into RNA. The cell would be able to enter mitosis but not complete it. The cell would still phosphorylate the CDK-associated target proteins, and would do so more quickly.
Which of the following is an example of a proto-oncogene? 1) cell cycle inhibitor 2) tumor suppressor 3) oncogene 4) repair enzyme 5) growth factor receptor
Ras is a proto-oncogene that is within the EGF pathway. The EGF receptor can activate the cell division pathway only when the EGF ligand binds to the receptor. A gain of function mutation occurs in only one copy of the Ras gene. What are all the possible consequences of this? Select all that apply. Group of answer choices The cell will undergo constant cell division The cell will still be normal as only one copy of Ras is mutated. Both copies must be mutated for the cell to undergo constant cell division There will be an increase of EGF ligands present in the cell The EGF receptor will always be active even with no EGF ligands bound and activate the pathway Ras will always be active and activate the proteins downstream that will turn on cell division Ras will be under the influence of the EGF receptor and will only activate if the EGF ligand is bound to the receptor
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